Home

  • 2019 ACS Biomacromolecules/Macromolecules Young Investigator Award
  • Degradable and functional polyestersAngew. Chem., Int. Ed. 2017, in press
  • Fluorescent polymer prodrug nanoparticlesChem. Commun. 2017, 53, 4489
  • Degradable vinyl polymers for biomedical applicationsNature Chem. 2015, 7, 771
  • Anticancer polyterpene prodrug nanoparticlesAngew. Chem., Int. Ed. 2013, 52, 6
  • Anticancer multifunctional polyester nanoparticlesChem. Mater. 2014, 26, 1834
  • Lipid-containing polymer prodrug nanoparticlesChem. Mater. 2014, 26, 3606
  • Multifunctional squalene-based nanoparticlesChem. Commun 2014, 50, 5336
  • Nanoparticles for brain endothelial cell imagingChem. Commun. 2010, 46, 2602
  • Amyloid-beta peptide-binding nanoparticlesACS Nano 2012, 6, 5897
  • Nanoparticles against cancer and AlzheimerACS Nano 2012, 6, 5866
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Welcome to my homepage

I'm currently CNRS Research Director and head of the group "Nanomedicines for the treatment of severe diseases" at Institut Galien Paris-Saclay (UMR CNRS 8612), at the Faculty of Pharmacy of Châtenay-Malabry, University Paris-Saclay, France.

The Institut Galien Paris-Sud aims to design, synthesize, characterize and evaluate new drug delivery systems for the controlled release and the targeting of drugs. Our research group is working on the use of nanomedicines for cancer therapy as well as neurodegenerative and infectious diseases.

My contributions in this multidisciplinary research group are based on advanced macromolecular synthesis, physico-chemistry of colloids and bioconjugation, in order to develop efficient and innovative polymer biomaterials and nanomedicines.

News


Publication

[Dec 16, 2020]

Chen's article titled "Towards Nanoparticles with Site-Specific Degradability by Ring-Opening Copolymerization Induced Self-Assembly in Organic Medium" is accepted in Polym. Chem.. Congrats!

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Publication

[Nov 13, 2020]

Theo's Viewpoint titled "Degradable Polymers from Radical Ring-Opening Polymerization (rROP): Latest Advances, New Directions and Ongoing Challenges" is accepted in ACS Macro Letters. Congrats!

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Presentation

[Oct 27, 2020]

Julien delivered an invited lecture titled "Well-Defined Polymer-Prodrug Conjugates for Cancer Therapy" at the 12th European and Global Summit for Nanomedicine congress (CLINAM 2020), Basel, Switzerland

Publication

[Oct 18, 2020]

Our collaborative paper titled "DFT Calculation-Assisted Prediction of the Copolymerization Between Cyclic Ketene Acetals with Traditional Vinyl Monomers" is accepted in Polymer Chemistry. Congrats to all!

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Publication

[Sep 14, 2020]

Amaury's paper titled "Synthesis of Poly(Asparagine-co-Phenylalanine) Copolymers, Analogy with Thermosensitive Poly(Acrylamide-co-Styrene) Copolymers and Formation of PEGylated Nanoparticles" is accepted in European Polymer Journal. Congrats!

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Publication

[Mar 31, 2020]

Our collaborative review article titled "3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence the Stem Cell Fate" is accepted in Biomacromolecules. Congrats to all!

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Presentation

[Dec 10, 2019]

Julien delivered an lecture titled "Heterotelechelic Polymer Prodrug Nanoparticles for Imaging and Combination Therapy" at the The SFNano - C'Nano Joint Meeting 2019, Dijon, France

Presentation

[Oct 1, 2019]

Julien delivered an lecture titled "Synthesis of Degradable Latexes by Radical Ring-Opening Polymerization in Dispersed Media" at the 36th Club Emulsion, Arkema, Colombes, France

Publication

[Sep 28, 2019]

Yi Yan Yang and Julien published in Nature Chemistry a Meeting Report about the 47th IUPAC congress titled "A Chemical Centenary to Celebrate"

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Presentation

[Aug 27, 2019]

Julien delivered an invited lecture titled "Degradable Vinyl Materials for Biomedical Applications from Controlled Radical Ring-Opening Copolymerization" and a lecture titled "Radical Ring-Opening Copolymerization-Induced Self-Assembly (rROPISA)" at the 258th American Chemical Society National Meeting & Exposition, San Diego, CA, USA

Presentation

[Jul 09, 2019]

Justin delivered a lecture titled "Degradable Vinyl Polymer Nanoparticles by Copolymerization-Induced Self-Assembly (rROPISA)" at the 47th IUPAC World Chemistry Congress, Paris, France. Well done!

Presentation

[Jul 08, 2019]

Julien delivered a lecture titled "Biodegradable Vinyl Polymers" and "Polymer Prodrug Nanocarriers for Anticancer Therapy" at the 47th IUPAC World Chemistry Congress, Paris, France.

Presentation

[Jul 03, 2019]

Justin and Théo delivered a lecture titled "Degradable Vinyl Polymer Nanoparticles by Copolymerization-Induced Self-Assembly (rROPISA)" and "Design of Degradable and Functionalized Vinyl Polymer Nanoparticles for Cardiac Therapy", respectively, at the Journée Annuelle du GFP Ile-de-France 2019, Neuville-sur-Oise, France. Well done guys!

Award

[Jun 28, 2019]

Julien is one of the 2 recipients of the 2019 Biomacromolecules/Macromolecules Young Investigator Award from the American Chemical Society! Many thanks to all past & present students/colleagues/collaborators who made this happened!

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Publication

[Jun 28, 2019]

Alexandre's paper titled "The Crucial Role of Macromolecular Engineering, Drug Encapsulation and Dilution on the Thermoresponsiveness of UCST Diblock Copolymer Nanoparticles Used for Hyperthermia" is accepted in European Journal of Pharmaceutics and Biopharmaceutics. Excellent news!

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Publication

[Jun 17, 2019]

Gianpiero's paper titled "Light Sheet Fluorescence Microscopy versus Confocal Microscopy: In Quest of a Suitable Tool to Assess Drug and Nanomedicine Penetration into Multicellular Tumor Spheroids" is accepted in European Journal of Pharmaceutics and Biopharmaceutics. Congrats!

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Publication

[Jun 6, 2019]

Alysia and Daniele's paper titled "Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier" is accepted in European Journal of Pharmaceutics and Biopharmaceutics. Congrats guys!

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Presentation

[Jun 04, 2019]

Julien delivered an invited lecture titled "New Polymers and Strategies for Drug Delivery Applications" at the 3rd BIOMAT congress - Materials for Health 2019, La Grande Motte, France.

Presentation

[May 23, 2019]

Julien delivered an invited lecture titled "Well-defined Polymer Prodrug Nanocarriers from the “Drug-initiated” Approach" at the CSPS/CC-CRS Annual Symposium, Vancouver, Canada.

Presentation

[Mar 31, 2019]

Julien delivered a lecture titled "Polymer prodrug nanocarriers for anticancer therapy" at the 257th American Chemical Society National Meeting & Exposition, Orlando, FL, USA

Presentation

[Mar 25, 2019]

Julien delivered an invited lecture titled "New Polymer-Based Drug Delivery Systems for Cancer Therapy " at the 3rd European Conference on Pharmaceutics, Bologna, Italy.

Publication

[Mar 18, 2019]

Elise's paper titled "Radical Ring-Opening Copolymerization-Induced Self-Assembly (rROPISA)" is accepted in Macromolecules. Congrats!

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Publication

[Mar 06, 2019]

Our collaborative article titled "Structure-pDNA Complexation and Structure-Cytotoxicity Relationships of PEGylated, Cationic Aminoethyl-Based Polyacrylates with Tunable Topologies" is accepted in Polymer Chemistry. Congrats to all!

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Publication

[Feb 02, 2019]

Our review article titled "From Poly(Alkyl Cyanoacrylate) to Squalene as Core Material to Design Nanomedicines" is accepted in Journal of Drug Targeting. Congrats to all!

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Publication

[Jan 23, 2019]

Divya's review article titled "Cathepsin-Sensitive Nanoscale Drug Delivery Systems for Cancer Therapy and other Diseases" is accepted in Advanced Drug Delivery Reviews. Great news!

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Publication

[Dec 28, 2018]

Daniele's article titled "Heterotelechelic Polymer Prodrug Nanoparticles: Adaptability to Different Drug Combinations and Influence of the Dual Functionalization on the Cytotoxicity" is accepted in Journal of Controlled Release. Congrats!

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Press

[Dec 18, 2018]

Interview by Novacap of Julien, Johanna and Daniele following the 2018 Novacap award of the French Academy of Sciences (in French).

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Event

[Dec 17, 2018]

Congratulations to Johanna who successfully defended his PhD, titled "Polyesters Fonctionnels par Polymérisation Radicalaire par Ouverture de Cycle, une Plateforme Nanoparticulaire pour la Délivrance de Principe Actif pour les Maladies Cardiovasculaires" in front of the following committee: Muriel Lansalot, Jean Coudane, Simon Harrisson, Didier Gigmes, Elias Fattal, Patrick Couvreur and Julien Nicolas.

Event

[Dec 13, 2018]

Congratulations to Alexandre who successfully defended his PhD, titled "Stratégies Alternatives pour la Délivrance D'anticancéreux par Encapsulation Physique dans des Nanoparticules Polymères Thermosensibles ou par Couplage Chimique en Prodrogues Polymères" in front of the following committee: Rachel Auzély, Dominique Hourdet, Elisabeth Garanger, Elias Fattal, Nicolas Tsapis and Julien Nicolas.

Event

[Dec 10, 2018]

Congratulations to Daniele who successfully defended his PhD, titled "Drug-Initiated Synthesis and Biological Evaluation of Heterotelechelic Polymer Prodrug Nanoparticles" in front of the following committee: Anne-Françoise Mingotaud, Bruno De Geest, Maria Jesus Vicent, Boris Vauzeilles, Francesco Nicotra, Yohann Guillaneuf, Patrick Couvreur and Julien Nicolas.

Award

[Dec 05, 2018]

Daniele received the best oral communication award at the SFNano 2018 congress in Montpellier. Congratulations!

Press

[Dec 05, 2018]

Interview of Julien by Université Paris-Saclay "Julien Nicolas: Boosting Drug Efficiency".

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Publication

[Nov 30, 2018]

Johanna's article titled "Degradable Copolymer Nanoparticles from Radical Ring-Opening Copolymerization between Cyclic Ketene Acetals and Vinyl Ethers" is accepted in Biomacromolecules. Congrats!

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Presentation

[Nov 14, 2018]

Julien delivered an invited lecture titled "Drug-Initiated Synthesis of Polymer Prodrug Nanocarriers for Anticancer Therapy" at the 5th International Conference on Electronic Materials and Nanotechnology for Green Environnement (ENGE 2018), Jeju, South Korea.

Award

[Oct 16, 2018]

Julien received the 2018 "Prix Novacap de l'Académie des Sciences" during the Award Ceremony at the French Academy of Sciences.

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Publication

[Oct 9, 2018]

Alexandre's review article titled "Thermoresponsive Polymer Nanocarriers for Biomedical Applications" is accepted in Advanced Drug Delivery Reviews. Congrats!

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Publication

[Oct 9, 2018]

Julien's collaborative Editorial titled "Best Practices for New Polymers and Nanoparticulate Systems - How Not To Be Soft With Reporting Standards" is published in Chemistry of Materials.

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Presentation

[Sep 15, 2018]

Julien delivered an invited lecture titled "Drug-Initiated Synthesis of Polymer Prodrug Nanocarriers for Anticancer Therapy" at the 5th Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2018), Suzhou, China.

Publication

[Aug 28, 2018]

Elise's article titled "Degradable Polymer Prodrugs with Adjustable Activity from Drug-Initiated Radical Ring-Opening Copolymerization" is accepted in Chemical Science. Excellent job!

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Publication

[Aug 05, 2018]

Daniele's article titled "A Facile Route to Heterotelechelic Polymer Prodrug Nanoparticles for Imaging, Drug Delivery and Combination Therapy" is accepted in Journal of Controlled Release. Congrats!

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Award

[Jul 25, 2018]

Julien received the 2018 Prix Novacap de l'Académie des Sciences for his outstanding research in the field of innovative polymers for biomedical applications.

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Presentation

[July 3, 2018]

Julien delivered an invited lecture titled "Synthesis of Degradable Vinyl Polymers for Biomedical Applications" at the French Chemical Society 2018 (SCF 18) congress, Montpellier, France.

Presentation

[May 28, 2018]

Julien delivered an invited lecture titled "Synthesis of Degradable Vinyl Polymers for Biomedical Applications" at the Bordeaux Polymer Conference (BPC 2018), Bordeaux, France.

Presentation

[Apr 11, 2018]

Julien delivered an invited lecture titled "Vinyl Polymers for Biomedical Applications" at the 15th European Symposium on Controlled Drug Delivery (ESCDD 2018), Egmond aan Zee, The Netherlands.

Press

[Mar 7, 2018]

Interview (in French) about Nanomedicine during the Radio show "La Méthode Scientifique" broadcasted on France Culture.

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Cover

[Feb 15, 2018]

Julien's invited Research article entitled "Self-Stabilized, Hydrophobic or PEGylated Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy" made the front cover of Polymer Chemistry!

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Publication

[Jan 22, 2018]

Elise's article titled "Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters" is accepted in Macromolecules. Bravo!

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Publication

[Dec 22, 2017]

Yinyin's article titled "Hydrophobic or PEGylated, Self-Stabilized Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy" is accepted in Polym. Chem. Congrats!

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Publication

[Dec 11, 2017]

Our collaborative article titled "Antibody-Functionalized Polymer Nanoparticle Leading to Memory Recovery in Alzheimer’s Disease-like Transgenic Mouse Model" is accepted in Nanomedicine NBM. Congrats to all!

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Grant

[Dec 18, 2017]

Julien has been awarded by an European Research Council (ERC) Consolidator grant (2018-2023) for a research project titled THERMONANO. The idea is to develop a new strategy for the administration of anticancer drug that is simple, efficient, comfortable for the patient and significantly less costly than traditional chemotherapies.

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Presentation

[Dec 4, 2017]

Johanna delivered a lecture titled "Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals: a New Platform to Challenge Traditional Polyesters for Biomedical Applications" at the SFNano 2017 meeting, Bordeaux, France. Bravo !

Event

[Nov 28, 2017]

Congratulations to Elise who successfully defended her PhD, titled "Degradable Polymer Prodrugs Synthesized by Nitroxide-Mediated Radical Ring-Opening Polymerization" in front of the following committee: Sophie Guillaume, Sagrario Pascual, Sébastien Lecommandoux, Philippe Guégan, Yohann Guillaneuf, Elias Fattal, Patrick Couvreur and Julien Nicolas.

Publication

[Nov 28, 2017]

Our feature article titled "Telechelic Polymers from Reversible-Deactivation Radical Polymerization for Biomedical Applications" is accepted in Chem. Commun. Congrats to all!

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Press release

[Nov 28, 2017]

Press release by the CNRS concerning our collaborative article in Angewandte Chemie, International Edition, titled: "Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters"

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Presentation

[Nov 22, 2017]

Julien delivered a lecture titled "New Polymers and Strategies for Drug Delivery Applications" at the GFP 2017 meeting, Paris, France.

Publication

[Nov 6, 2017]

Our collaborative paper (with Didier Gigmes and Didier Letourneur's groups) titled "Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters" is accepted in Angew. Chem., Int. Ed. Congrats to all!

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Presentation

[Oct 17, 2017]

Elise delivered a lecture titled "Development of Degradable Polymer Prodrug Nanoparticles for Cancer Therapy" at the 34ème Club Emulsion, Lyon, France. Congrats!

Publication

[Oct 14, 2017]

Julien published a collaborative article in l'Actualité Chimique (in French) titled: "Polymères et Interactions avec les Milieux Biologiques" as part of a themed issue titled "Polymères de Demain, Boosters d'Innovations".

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Presentation

[Sep 19, 2017]

Julien delivered an invited lecture titled "Innovative Polymers for Drug Delivery Applications" at the Chemistry division of the French Academy of Sciences, Paris, France.

Publication

[Sep 14, 2017]

Megan's paper (collaboration with Brent Sumerlin's group) titled "Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units" is accepted in ACS Macro Letters. Congrats!

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Presentation

[Aug 21, 2017]

Julien delivered an invited lecture titled "New Polymers and Strategies for Drug Delivery Applications" at the 254th American Chemical Society National Meeting & Exposition, Washington, DC, USA.

Presentation & Award

[Jun 23, 2017]

Elise delivered a lecture and received the second best oral communication award during the 2017 Doctoral School meeting in Châtenay-Malabry, France. Bravo !!

Award

[May 23, 2017]

Julien received the 2017 Polymer Chemistry Lectureship award by Associate Editor Christopher Barner-Kowollik during the Advanced Polymers via Macromolecular Engineering (APME) 2017 congress in Ghent, Belgium.

Presentation

[May 23, 2017]

Julien delivered an invited lecture titled "New Polymers and Strategies for Drug Delivery Applications" at the Advanced Polymers via Macromolecular Engineering (APME) 2017 congress in Ghent, Belgium.

Publication

[Apr 19, 2017]

Yinyin's paper titled "Structure-Cytotoxicity Relationship of Drug-Initiated Polymer Prodrug Nanoparticles" is accepted in Polym. Chem. Congrats Yinyin!

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Publication

[Mar 29, 2017]

Yinyin's paper titled "Fluorescent Polymer Prodrug Nanoparticles with Aggregation-Induced Emission (AIE) Properties from Nitroxide-Mediated Polymerization" is accepted in Chem. Commun. Congrats Yinyin!

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Publication

[Mar 29, 2017]

Our collaborative article titled "A Comprehensive Kinetic Study of the Conventional Free-Radical Polymerization of Seven-Membered Cyclic Ketene Acetals" is accepted in Polym. Chem. Congratulations to all!

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Seminar

[Mar 17, 2017]

Julien presented a seminar titled "Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles" during the minisymposium "Polymers for Medicine" at the Institute of Materials, EPFL

Publication

[Jan 20, 2017]

Our Perspective article titled "Polymer Nanoparticles for the Delivery of Anticancer Drugs" is accepted in Med./Sci.

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Vacancies

There are currently no vacancies but you can still join us with your own funding or by applying for national, european or international research grants

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