Publications Show graphical abstracts


2017

[83] Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units. Hill, M. R.; Guégain, E.; Tran, J.; Figg, C. A.; Turner, A. C.; Nicolas, J.*, Sumerlin, B. S.* ACS Macro Lett. 2017, in press. DOI: 10.1021/acsmacrolett.7b00572

[82] Structure-Cytotoxicity Relationship of Drug-Initiated Polymer Prodrug Nanoparticles. Bao.; Y.; Nicolas, J.* Polym. Chem. 2017, 8, 5174. DOI: 10.1039/c7py00536a

[81] Fluorescent Polymer Prodrug Nanoparticles with Aggregation-Induced Emission (AIE) Properties from Nitroxide-Mediated Polymerization. Bao.; Y.; Guégain, E.; Nicolas, V.; Nicolas, J.* Chem. Commun. 2017, 53, 4489. DOI: 10.1039/c6cc09052d

[80] A Comprehensive Kinetic Study of the Conventional Free-Radical Polymerization of Seven-Membered Cyclic Ketene Acetals. Tardy, A.; Honoré, J.-C.; Siri, D.; Nicolas, J.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.* Polym. Chem. 2017, in press. DOI: 10.1039/c7py00337d

[79] Polymer Nanoparticles for the Delivery of Anticancer Drugs. Nicolas, J.;* Couvreur. P. Med./Sci. 2017, 33, 11. DOI: 10.1051/medsci/20173301003

[78] Radical Ring-Opening Polymerization: Scope, Limitations and Application to (Bio)Degradable Materials. Tardy, A.; Nicolas, J.; Gigmes, D.; Lefay, C.;* Guillaneuf, Y.* Chem. Rev. 2017, 117, 1319. DOI: 10.1021/acs.chemrev.6b00319


2016

[77] Pulmonary Surfactant Protein A: A Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages. Ruge, C. A.; Hillaireau, H.; Grabowski, N.; Beck-Broichsitter, M.; Cañadas, O.; Tsapis, N.; Casals, C.; Nicolas, J.; Fattal, E.* Mol. Pharm. 2016, 13, 4168. DOI: 10.1021/acs.chemmater.6b02502

[76] Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tuneable Drug Delivery Properties. Bao, Y.; Boissenot, T.; Guégain, E.; Desmaële, D.; Mura, S.; Couvreur, P.; Nicolas, J.* Chem. Mater. 2016, 28, 6266. DOI: 10.1021/acs.chemmater.6b02502

[75] Efficient Synthesis of 2-Methylene-4-Phenyl-1,3-Dioxolane, a Cyclic Ketene Acetal for Controlling the NMP of Methyl Methacrylate and Conferring Tunable Degradability. Tran, J.; Guégain, E.; Ibrahim, N.; Harrisson, S.; Nicolas, J.* Polym. Chem. 2016, 7, 4427. DOI: 10.1039/c6py00778c

[74] Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery. Nicolas, J.* Chem. Mater. 2016, 28, 1591. DOI: 10.1021/acs.chemmater.5b04281 (invited Perspective article)

[73] Nitroxide-Mediated Polymerization of Vinyl Chloride at Low Temperature: Kinetic and Computational Studies. Abreu, C. M. R.; Mendonça, P. V.; Serra, A. C.; Noble, B. B.; Guliashvili, T.;* Nicolas, J.;* Coote, M. L.;* Coelho, J. F. J.* Macromolecules 2016, 49, 490. DOI: 10.1021/acs.macromol.5b02017

[72] Cyclopentyl Methyl Ether as a Green Solvent for Reversible-Addition Fragmentation Chain Transfer and Nitroxide-Mediated Polymerizations. Abreu, C. M. R.; Maximiano, P.; Guliashvili, T.; Nicolas, J.;* Serra, A. C.; Coelho, J. F. J.* RSC Advances 2016, 6, 7495. DOI: 10.1039/c5ra21975b


2015

[71] Degradable Vinyl Polymers for Biomedical Applications. Delplace, V.; Nicolas, J.* Nature Chem. 2015, 7, 771. DOI: 10.1038/nchem.2343

[70] A Ring to Rule Them All: A Cyclic Ketene Acetal Comonomer Controls the Nitroxide-Mediated Polymerization of Methacrylates and Confers Tunable Degradability. Delplace, V.; Guégain, E.; Harrisson, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Chem. Commun. 2015, 51, 12847. DOI: 10.1039/c5cc04610f

[69] Solvent Selection Causes Remarkable Shifts of the “Ouzo Region” for Poly(Lactide-co-Glycolide) Nanoparticles Prepared by Nanoprecipitation. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Nanoscale 2015, 7, 9215. DOI: 10.1039/c5nr01695a

[68] Design Attributes of Long-Circulating Polymeric Drug Delivery Vehicles. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Eur. J. Pharm. Biopharm. 2015, 97, Part B, 304. DOI: 10.1016/j.ejpb.2015.03.033

[67] One-Step Synthesis of Azlactone-Functionalized SG1-Based Alkoxyamine for Nitroxide-Mediated Polymerization and Bioconjugation. Delplace, S.; Harrisson, S.; Ho, H. T.; Tardy, A.; Guillaneuf, Y.; Pascual, S.; Fontaine, L.; Nicolas, J.* Macromolecules 2015, 48, 2087. DOI: 10.1021/acs.macromol.5b00178

[66] On the Structure-Control Relationship of Amide-Functionalized SG1-Based Alkoxyamines for Nitroxide-Mediated Polymerization and Conjugation. Guégain, E.; Delplace, V.; Trimaille, T.; Gigmes, D.; Siri, D.; Marque, S.; Guillaneuf, Y.; Nicolas, J.* Polym. Chem. 2015, 6, 5693, DOI: 10.1039/c5py00283d. [Feature article in Polym. Chem. Emerging Investigator issue 2015]

[65] Nitroxide-Mediated Polymerization of Methacrylic Esters: Insights and Solutions to a Long Standing Problem. Guégain, E.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2015, 36, 1227. DOI: 10.1002/marc.201500042. [Cover]

[64] Lipid Prodrug Nanocarriers in Cancer Therapy. Mura, S.;* Bui, D. T., Couvreur, P.; Nicolas, J.* J. Control. Release 2015, 28, 25. DOI: 10.1016/j.jconrel.2015.01.021


2014

[63] In the (Very) Long Run We Are All Dead: Activation and Termination in SET-LRP/SARA-ATRP. Harrisson, S.;* Nicolas, J. ACS Macro Lett. 2014, 3, 643. DOI: 10.1021/mz500305j

[62] Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method. Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur P.; Nicolas, J.* Chem. Mater. 2014, 26, 3606. DOI: 10.1021/cm501500k

[61] Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Mackiewicz, N.; Nicolas, J.;* Handké, N.; Noiray, M.; Mougin, J.; Daveu, C.; Reddy, L. H.; Bazile, D.; Couvreur, P. Chem. Mater. 2014, 26, 1834. DOI: 10.1021/cm403822w

[60] RGD Decoration of PEGylated Polyester Nanocapsules of Perfluorooctyl Bromide for Tumor Imaging: Influence of Pre- or Post-Functionalization on Capsule Morphology. Diou, O.; Fattal, E.; Delplace, V.; Mackiewicz, N.; Nicolas, J.; Mériaux, S.; Valette, J.; Robic, C.; Tsapis, N.* Eur. J. Pharm. Biopharm. 201487, 170. DOI: 10.1016/j.ejpb.2013.12.003

[59] Nitroxide-Mediated Radical Ring-Opening Copolymerization: Chain-End Investigation and Block Copolymer Synthesis. Delplace, V.; Harrisson, S.; Tardy, A.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2014, 35, 484. DOI: 10.1002/marc.201300809

[58] Recent Trends in the Design of Anticancer Polymer Prodrug Nanocarriers. Delplace, V.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2014, 5, 1529. DOI: 10.1039/c3py01384g

[57] Multifunctional Squalene-Based Prodrug Nanoparticles for Targeted Cancer Therapy. Bui, D. T.; Nicolas, J.;* Maksimenko, A.; Desmaële, D.; Couvreur, P. Chem. Commun. 2014, 50, 5336. DOI: 10.1039/c3cc47427e. [Feature article in Chem. Commun. Emerging Investigator issue 2014]


2013

[56] Degradable PEG-Based and Comblike Copolymers by Nitroxide-Mediated Radical Ring-Opening Polymerization. Delplace, V.; Tardy, A.; Harrisson, S.; Mura, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Biomacromolecules 2013, 14, 3769. DOI: 10.1021/bm401157g

[55] Stimuli-Responsive Nanocarriers for Drug Delivery. Mura, S.; Nicolas, J.; Couvreur, P.* Nature Mater. 2013, 12, 991. DOI: 10.1038/nmat3776

[54] Polymer Prodrug Nanoparticles Based on Naturally Occurring Isoprenoid for Anticancer Therapy. Bui, D. T.; Maksimenko, A.; Desmaële, D.; Harrisson, S.; Vauthier, C.; Couvreur, P.; Nicolas, J.* Biomacromolecules 2013, 14, 2837. DOI: 10.1021/bm400657g

[53] Scope and Limitations of the Nitroxide-Mediated Radical Ring Opening Polymerization of Cyclic Ketene Acetals. Tardy, A.; Delplace, V.; Siri, D.; Lefay, C.; Harrisson, S.; de Fatima Albergaria Pereira, B.; Charles, L.; Gigmes, D.;* Nicolas, J.; Guillaneuf, Y.* Polym. Chem. 2013, 4, 4776. DOI: 10.1039/c3py00719g. [Paper of the week]

[52] Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one ß-Carboline Series and Study of Phenotypic Properties on C. elegans. Cebrián-Torrejón, G.; Mackiewicz, N.; Vázquez-Manrique, R.; Fournet, A.; Figadère, B.; Nicolas, J.; Poupon, E.* Eur. J. Org. Chem. 2013, 5821. DOI: 10.1002/ejoc.201300770. [Cover]

[51] Effect of Nanoparticles Binding Beta-Amyloid Peptide on Nitric Oxide Production by Cultured Endothelial Cells and Macrophages. Orlando, F.; Re, F.; Sesana, S.; Rivolta, I.; Panariti, A.; Brambilla, D.; Nicolas, J.; Couvreur, P.; Andrieux, K.; Masserini, M.; Cazzaniga, E. Int. J. Nanomed. 2013, 8, 1335. DOI: 10.2147/ijn.s40297

[50] Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Harrisson, S.; Nicolas, J.;* Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Angew. Chem., Int. Ed. 2013, 52, 1678. DOI: 10.1002/anie.201207297

[49] Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate). Babinot, J.; Le Droumaguet, B.; Renard, E.; Guigner, J.-M.; Mura, S.; Nicolas, J.; Couvreur, P.; Langlois, V.* Macromol. Rapid Commun. 2013, 34, 362. DOI: 10.1002/marc.201200692

[48] Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanoparticles for Drug Delivery. Nicolas, J.;* Mura, S.; Brambilla, D.; Mackiewicz, N.; Couvreur, P. Chem. Soc. Rev. 2013, 42, 1147. DOI: 10.1039/c2cs35265f

[47] Nitroxide-Mediated Polymerization. Nicolas, J.;* Guillaneuf, Y.;* Lefay, C.; Bertin, D.; Gigmes, D.; Charleux, B. Prog. Polym. Sci. 2013, 38, 63. DOI: 10.1016/j.progpolymsci.2012.06.002


2012

[46] Comproportionation versus Disproportionation in the Initiation step of Cu(0)-Mediated Living Radical Polymerization. Harrisson, S.;* Couvreur, P.; Nicolas, J.* Macromolecules 2012, 45, 7388. DOI: 10.1021/ma301034t

[45] PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Towards Engineering of Functional Nanomedicines for Alzheimer’s Disease. Brambilla, D.; Verpillot, R.; Le Droumaguet, B.; Nicolas, J.; Taverna, M.; Kóna, J.; Lettiero, B.; Hashemi, S. H.; De Kimpe, L.; Canovi, M.; Gobbi, M.; Nicolas, V.; Scheper, W.; Moghimi, S. M.; Tvaroška, I.; Couvreur, P.; Andrieux, K.* ACS Nano 2012, 6, 5897. DOI: 10.1021/nn300489k

[44] Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. Le Droumaguet, B.; Nicolas, J.;* Brambilla, D.; Mura, S.; Maksimenko, A.; De Kimpe, L.; Salvati, E.; Zona, C.; Airoldi, C.; Canovi, M.; Gobbi, M.; Noiray, M.; La Ferla, B.; Nicotra, F.; Scheper, W.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. ACS Nano 2012, 6, 5866. DOI: 10.1021/nn3004372

[43] Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications. Harivardhan Reddy, L.; Arias, J. L.; Nicolas, J.; Couvreur, P.* Chem. Rev. 2012, 112, 5818. DOI: 10.1021/cr300068p

[42] Use of Solvent Effects to Improve Control over Nitroxide-Mediated Polymerization of Isoprene. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromol. Rapid Commun. 2012, 33, 805. DOI: 10.1002/marc.201100866. [Feature article in Macromol. Rapid Commun. Polymer Science: The Next Generation issue]

[41] NIR-Labelling of PLGA Nanoparticles for In Vivo Imaging. Reul, R.; Tsapis, N.*; Hillaireau, H.; Sancey, L.; Mura, S.; Recher, M.; Nicolas, J.; Coll, J.-L.; Fattal, E. Polym. Chem. 2012, 3, 694. DOI: 10.1039/c2py00520d


2011

[40] SG1 Nitroxide-Mediated Polymerization of Isoprene: Alkoxyamine Structure/Control Relationship and a,w-Chain-End Functionalization. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromolecules 2011, 44, 9230. DOI: 10.1021/ma202078q

[39] Biodegradable Nanoparticles Meet the Bronchial Airway Barrier: How Surface Properties Affect Their Interaction with Mucus and Epithelial Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Kerdine-Römer, S.; Le Droumaguet, B.; Deloménie, C.; Nicolas, V.; Pallardy, M.; Tsapis, N.; Fattal, E.* Biomacromolecules 2011, 12, 4136 . DOI: 10.1021/bm201226x

[38] Influence of Surface Charge on the Potential Toxicity of PLGA Nanoparticles Towards Calu-3 Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Le Droumaguet, B.; Geutin, C.; Zanna, S.; Tsapis, N.; Fattal, E.* Int. J. Nanomed. 2011, 6, 2591. DOI: 10.2147/ijn.s24552

[37] Colloidal Properties of Biodegradable Nanoparticles Influence Interaction with Amyloid-ß Peptide. Brambilla, D.; Souguir, H., Nicolas, J.;* Mackiewicz, N.; Verpillot, R.; Le Droumaguet, B.; Taverna, M.; Couvreur, P.; Andrieux, K. J. Biotechnol. 2011, 156, 338. DOI: 10.1016/j.jbiotec.2011.07.020

[36] Quantum Dot-Loaded PEGylated Poly(alkyl cyanoacrylate) Nanoparticles for In Vitro and In Vivo Imaging. Nicolas, J.;* Brambilla, D.; Carion, O.; Pons, T.; Maksimovic, I.; Larquet, E.; Le Droumaguet, B.; Andrieux, K.; Dubertret, B.; Couvreur, P. Soft Matter 2011, 7, 6187. DOI: 10.1039/c1sm05529a

[35] Simple and Efficient Copper Metal-Mediated Synthesis of Alkoxyamines. Harrisson, S.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1853. DOI: 10.1039/c1py00131k

[34] Nanotechnologies and Alzheimer’s Disease: Diagnosis, Therapy and Safety Issues. Brambilla, D.; Le Droumaguet, B.; Nicolas, J.;* Hashemi, S. H.; Wu, L.-P.; Moghimi, S. M.; Couvreur, P.; Andrieux, K. Nanomedicine: NBM 2011, 7, 521. DOI: 10.1016/j.nano.2011.03.008

[33] First Peptide/Protein PEGylation with Functional Polymers Designed by Nitroxide-Mediated Polymerization. Chenal, M.; Boursier, C.; Guillaneuf, Y.; Taverna, M.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1523. DOI: 10.1039/c1py00028d

[32] Selegiline-Functionalized, PEGylated Poly(alkyl cyanoacrylate) Nanoparticles: Investigation of Interaction with Amyloid-ß Peptide and Surface Reorganization. Le Droumaguet, B.; Souguir, H.; Brambilla, D.; Verpillot, R.; Nicolas, J.;* Taverna, M.; Couvreur, P.; Andrieux, K.* Int. J. Pharm. 2011, 416, 453. DOI: 10.1016/j.ijpharm.2011.01.015


2010

[31] A New Method Based on Capillary Electrophoresis with Laser-Induced Fluorescence Detection (CE-LIF) to Monitor Interaction Between Nanoparticles and the Amyloid-ß Peptide. Brambilla, D.; Verpillot, R.; Taverna, M.*; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. Anal. Chem. 2010, 82, 10083. DOI: 10.1021/ac102045x

[30] Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions. Chenal, M.; Mura, S.; Marchal, C.; Gigmes, D.; Charleux, B.; Fattal, E.; Couvreur, P.; Nicolas, J.* Macromolecules 2010, 43, 9291. DOI: 10.1021/ma101880m

[29 PEGylation and Preliminary Biocompatibility Evaluation of Magnetite-Silica Nanocomposites Obtained by High Energy Ball Milling. Pilloni, M.; Nicolas, J.;* Marsaud, V.; Bouchemal, K.; Frongia, F.; Scano, A.; Ennas, G.; Dubernet, C. Int. J. Pharm. 2010, 401, 103. DOI: 10.1016/j.ijpharm.2010.09.010

[28] Design of Fluorescently Tagged Poly(alkyl cyanoacrylate) Nanoparticles for Human Brain Endothelial Cell Imaging. Brambilla, D.; Nicolas, J.;* Le Droumaguet, B.; Andrieux, K.*; Marsaud, V.; Couraud, P.-O.; Couvreur, P. Chem. Commun. 2010, 46, 2602. DOI: 10.1039/b924028d

[27] Recent Advances in the Design of Bioconjugates from Controlled/Living Radical Polymerization. Le Droumaguet, B.; Nicolas, J.* Polym. Chem. 2010, 1, 563. DOI: 10.1039/b9py00363k. [Cover]

[26] A Minimal Amount of Acrylonitrile Turns the Nitroxide-Mediated Polymerization of Methyl Methacrylate Into an Almost Ideal Controlled/Living System. Nicolas, J.;* Brusseau, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 34. DOI: 10.1002/pola.23749


2009

[25] Formulation of Didanosine Prodrugs into PEGylated Poly(alkyl cyanoacrylate) Nanoparticles and Uptake by Brain Endothelial Cells. Pierson, L.-A; Nicolas, J.; Lalanne, M.; Brambilla, D.; Marsaud, V.; Nicolas, V.; Ball, R.; Stanimirovic, D.; Couvreur, P.; Andrieux, K.* J. Nanoneurosci. 2009, 1, 174. DOI: 10.1166/jns.2009.1007

[24] Application of Thermal Analysis to the Study of Lipidic Prodrug Incorporation Into Nanocarriers. Bourgeois, J.; Pierson, L.-A.; Nicolas, J.; Lalanne, M.; Couvreur, P.; Andrieux, K.* J. Therm. Anal. Cal. 2009, 98, 65. DOI: 10.1007/s10973-009-0350-7

[23] Comprehensive Modeling Study of Nitroxide-Mediated Controlled/Living Radical Copolymerization of Methyl Methacrylate with a Small Amount of Styrene. Nicolas, J.;* Mueller, L.; Dire, C.; Matyjaszewski, K.; Charleux, B.* Macromolecules 2009, 44, 4470. DOI: 10.1021/ma900515v

[22] Synthesis of Poly(alkyl cyanoacrylate)-Based Colloidal Nanomedicines. Nicolas, J.;* Couvreur, P. Wiley Interdiscipl. Rev. Nanomed. Nanobiotechnol. 2009, 1, 111. DOI: 10.1002/wnan.15


2008

[21] Novel PEGylated Nanoassemblies Made of Self-Assembled Squalenoyl Nucleoside Analogues. Bekkara-Aounallah, F.; Gref, R.*; Othman, M.; Reddy, H.; Pili, B.; Allain, V.; Bourgaux, C.; Hillaireau, H.; Lepêtre-Mouelhi, S.; Desmaële, D.; Nicolas, J.; Chafi, N.; Couvreur, P. Adv. Funct. Mater. 2008, 18, 3715. DOI: 10.1002/adfm.200800705

[20] Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry. Nicolas, J.;* Bensaid, F.; Desmaële, D.; Grogna, M.; Detrembleur, D.; Andrieux, K.; Couvreur, P. Macromolecules 2008, 41, 8418. DOI: 10.1021/ma8013349

[19] Beta-Hydrogen Transfer from Poly(methyl methacrylate) Propagating Radicals to the Nitroxide SG1: Analysis of the Chain-end and Determination of the Rate Constant. Dire, C.; Belleney, J.; Nicolas, J.; Bertin, D.; Magnet, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 6333. DOI: 10.1002/pola.22945

[18] Comblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical Polymerization. Nicolas, J.;* Couvreur, P.; Charleux, B. Macromolecules 2008, 41, 3758. DOI: 10.1021/ma800609b

[17] Separation of Complex Branched Polymers by Size-Exclusion Chromatography Probed with Multiple Detection. Gaborieau, M.; Nicolas, J.; Save, M.; Charleux, B.; Vairon, J.-P.; Gilbert, R. G.; Castignolles, P.* J. Chromatogr. A 2008, 1190, 215. DOI: 10.1016/j.chroma.2008.03.031


2007

[16] Site-Directed Conjugation of "Clicked" Glycopolymers to Form Glycoprotein Mimics: Binding to Mammalian Lectin and Induction of Immunological Function. Geng, J.; Mantovani, G.*; Tao, L.; Nicolas, J.; Chen, G.; Wallis, R.; Mitchell, D. A.; Johnson, B. R. G.; Evans, S. D.; Haddleton, D. M.* J. Am. Chem. Soc. 2007, 129, 15156. DOI: 10.1021/ja072999x

[15] Nanostructured Latex Particles Synthesized by Nitroxide-Mediated Controlled/Living Free-Radical Polymerization in Emulsion. Nicolas, J.;* Ruzette, A.-V.; Farcet, C.; Gérard, P.; Magnet, S.; Charleux, B.* Polymer 2007, 48, 7029. DOI: 10.1016/j.polymer.2007.09.039

[14] Water-Soluble SG1-Based Alkoxyamines: a Breakthrough in Controlled/Living Free-Radical Polymerization in Aqueous Dispersed Media. Charleux, B.*; Nicolas, J. Polymer 2007, 48, 5813. DOI: 10.1016/j.polymer.2007.07.031. [Cover]

[13] Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates. Nicolas, J.;* Mantovani, G.; Haddleton, D. M.* Macromol. Rapid Commun. 2007, 28, 1083. DOI: 10.1002/marc.200700112

[12] Bioconjugation onto Biological Surfaces with Fluorescently Labeled Polymers. Nicolas, J.; Khoshdel, E.; Haddleton, D. M.* Chem. Commun. 2007, 1722. DOI: 10.1039/b617596a


2006

[11] Living Character of Polymer Chains Prepared via Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate in the Presence of a Small Amount of Styrene at Low Temperature. Nicolas, J.; Dire, C.; Mueller, L.; Belleney, J.; Charleux, B.*; Marque, S. R. A.; Bertin, D.; Magnet, S.; Couvreur, L. Macromolecules 2006, 39, 8274. DOI: 10.1021/ma061380x

[10] Fluorescently Tagged Polymer Bioconjugates from Protein Derived Macroinitiators. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M.* Chem. Commun. 2006, 4697. DOI: 10.1039/b609935a

[9] Multistep and Semi-Batch Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization: A Significant Step Toward Conceivable Industrial Processes. Nicolas, J.; Charleux, B.*; Magnet, S. J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 4142. DOI: 10.1002/pola.21519

[8] Aqueous Suspension of Amphiphilic Diblock Copolymer Nanoparticles Prepared in Situ from a Water-Soluble Poly(sodium acrylate) Alkoxyamine Macroinitiator. Delaittre, G.; Nicolas, J.; Lefay, C.; Save,M.; Charleux, B.* Soft Matter 2006, 2, 223. DOI: 10.1039/b515267d


2005

[7] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization Using a Difunctional Water-Soluble Alkoxyamine Initiator. Toward the Control of Particle Size, Particle Size Distribution and the Synthesis of Triblock Copolymers. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2005, 38, 9963. DOI: 10.1021/ma0511999

[6] Miniemulsion Polymerization of Styrene using a pH-Responsive Cationic Diblock Copolymer and its Reactive Copolymer Counterpart as Stabilizers. Houillot, L.; Nicolas, J.; Save, M.*; Charleux, B.; Li, Y.; Armes, S. P. Langmuir 2005, 21, 6726. DOI: 10.1021/la050495b

[5] Theoretical Expression of the Average Activation-Deactivation Equilibrium Constant in Controlled/Living Free-Radical Copolymerization Operating via Reversible Termination. Application to a Strongly Improved Control in Nitroxide-Mediated Polymerization of Methyl Methacrylate. Charleux, B.*; Nicolas, J.; Guerret, O. Macromolecules 2005, 38, 5485. DOI: 10.1021/ma050087e

[4] Surfactant-Free Synthesis of Amphiphilic Diblock Copolymer Nanoparticles via Nitroxide-Mediated Controlled Free-Radical Polymerization. Delaittre, G.; Nicolas, J.; Lefay, C.; Save, M.; Charleux, B.* Chem. Commun. 2005, 614. DOI: 10.1039/b415959d


2004

[3] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization of Styrene and n-Butyl Acrylate Using a Water-Soluble Alkoxyamine. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Angew. Chem., Int. Ed. 2004, 43, 6186. DOI: 10.1002/anie.200460704

[2] Novel SG1-Based Water-Soluble Alkoxyamine for Nitroxide-Mediated Controlled Free-Radical Polymerization of Styrene and n-Butyl Acrylate in Miniemulsion. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2004, 37, 4453. DOI: 10.1021/ma049800a


2002

[1] Kinetic Study of Nitroxide-Mediated Controlled Free-Radical Polymerization of n-Butyl Acrylate in Aqueous Miniemulsion. Farcet, C.; Nicolas, J.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 4410. DOI: 10.1002/pola.10531

Editorials


2011

[1] Editorial. Fattal, E.;* Nicolas, J.; Tsapis, N. Int. J. Pharm. 2011, 416, 401. DOI: 10.1016/j.ijpharm.2011.05.018

Patents


2014

[5] Couvreur, P.; Nicolas, J.; Blin, T.; Chtourou, A.; Genevaz, N. Copolymers of Formula (I) and Uses. Patent WO 2015181504 (with LFB)


2012

[4] Bazile, D.; Couvreur, P.; Lakkireddy, H.; Nicolas, J. Functional PLA-PEG Copolymers, the Nanoparticles Thereof, their Preparation and Use for Targeted Drug Delivery and Imaging. Patent WO 2013127949 (with Sanofi)


2007

[3] Haddleton, D. M.; Khoshdel, E.; Nicolas, J. A Method for Derivatizing Hair with a Reactive Polyethylene Glycol. Patent WO 2008058989 (with Unilever)


2006

[2] Gérard, P.; Magnet, S.; Guerret, O.; Nicolas, J.; Charleux, B. Method for Preparing a Living Polymer Comprising Methacrylic and/or Methacrylate Units. Patent WO 2007057620 (with Arkema)


2004

[1] Charleux, B.; Guerret, O.; Magnet, S.; Nicolas, J. Method for Radical Emulsion Polymerization Using Hydrosoluble Alkoxyamines. Patent WO 2005082945 (with Arkema)

Book chapters


2016

[13] Bioconjugates and Biomaterials Prepared by Nitroxide-Mediated Polymerization. Harth, E. M.; Nicolas, J.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-3-642-29647-5

[12] Nitroxide-Mediated Polymerization of Methacrylic Esters: How to Circumvent a Long-Time Obstacle. Nicolas, J.; Guégain, E.; Guillaneuf, Y.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-3-642-29647-5


2015

[11] The Drug-Initiated Method: A Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles. Harrisson, S.; Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur, P.; Nicolas, J.* In Controlled Radical Polymerization: Materials; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 257-272. DOI: 10.1021/bk-2015-1188.ch016

[10] Kinetic Studies of Elementary Reactions in SET-LRP / SARA ATRP. Nicolas, J.; Perrier, S.; Harrisson, S.* In Controlled Radical Polymerization: Mechanisms; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 129-143. DOI: 10.1021/bk-2015-1187.ch007


2014

[9] Living Radical Polymerization: Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y. In Encyclopedia of Polymeric Nanomaterials; Kobayashi, S. and Mullen, K. Eds.; Springer: New York, 2014, 1-16. ISBN 978-3-642-29647-5

[8] Polymer-Protein/Peptide Bioconjugates. Wilson, P.; Nicolas, J.; Haddleton, D. M. In Chemistry of Organo-Hybrids: Synthesis and Characterization of Functional Nano-Objects; Lacôte, E.; Charleux, B.; Copéret, C. Eds.; Wiley-VCH, 2014, 465-502. ISBN: 978-1-118-37902-8


2013

[7] Polymeric Nanoparticles for Drug Delivery. Andrieux, K.; Nicolas, J.; Moine, L.; Barrat, G. In Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, Volume 2; Dumitriu, S.; Popa, V. Eds.; CRC Press, 2013, 123-151. ISBN: 978-1420094688


2012

[6] Targeted Delivery Using Biodegradable Polymeric Nanoparticles. Fattal, E.; Hillaireau, H.; Mura, S.; Nicolas, J.; Tsapis, N. In Fundamentals and Applications of Controlled Release Drug Delivery; Siepmann, J.; Siegel, R. A.; Rathbone, M. J. Eds.; Advances in Delivery Science and Technology Series; Controlled Release Society, Springer, 2012, 255-288. ISBN: 978-1461408802

[5] Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y.; Bertin, D.; Gigmes, D.; Charleux, B. In Polymer Science: A Comprehensive Reference; Matyjaszewski, K.; Möller, M. Eds.; Elsevier, 2012, 3, 277. ISBN: 978-0444533494


2011

[4] Poly(alkyl cyanoacrylate) Nanosystems. Nicolas, J.; Vauthier, C. In Intracellular Delivery: Fundamentals and Applications; Fundamental Biomedical Technologies; Prokop, A. Ed.; Springer, 2011, 225-250. ISBN: 978-9400712478


2010

[3] Controlled/Living Radical Polymerization in Aqueous Miniemulsion. Lefay, C.; Nicolas, J. In Miniemulsion Polymerization Technology; Mittal, V. Ed.; Scrivener Publishing: Salem, MA, 2010, 173-210. ISBN: 978-0470625965


2009

[2] Nitroxide-Mediated Controlled Free-Radical Copolymerization of Poly(ethylene glycol) Methyl Ether Methacrylate and Methacrylic Acid. Toward New Water-Soluble Macroinitiators. Dire, C.; Nicolas, J.; Brusseau, S.; Charleux, B.; Magnet, S.; Couvreur, L. In Controlled/Living Radical Polymerization: Progress in RAFT, NMP & OMRP; Matyjaszewski, K. Ed.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2009, Vol. 1024, 303-318. DOI: 10.1021/bk-2009-1024.ch020


2008

[1] Fluorescently Labeled Protein-Polymer Bioconjugates Using Protein Derived Macroinitiators from Living Radical Polymerization. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M. In Polymers for Biomedical Applications; Mahapatro, A.; Kulshrestha, A. S. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2008, Vol. 977, 78-94. DOI: 10.1021/bk-2008-0977.ch006

Proceedings


2014

[23] Novel Nanoparticles with In Vivo Anticancer Activity from Well-​Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-650

[22] Nitroxide-​Mediated Radical Ring-Opening Copolymerization: Towards the Design of Block Copolymers Comprising a Degradable Block. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-343

[21] Comproportionation, Activation, and Termination in SET LRP​/SARA ATRP. Harrisson, S.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-222

[20] Toward Radical Ring-​Opening Living Polymerization via NMP: End-​Chain Characterization, Livingness, and Control. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-17

[19] New Biodegradable PEG-​Based Copolymers Synthesized by Nitroxide-​Mediated Radical Ring-​Opening Polymerization, for Biomedical Applications. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-624

[18] Novel Multifunctional Polymer Nanoparticles for Active Targeting in Drug Delivery: Application to Cancer and Alzheimer's Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Andrieux, K.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, COLL-397


2012

[17] Gemcitabine-Polyisoprenoid Nanoparticles for Potential Application in Cancer Therapy. Nicolas, J.; Bui, D. T.; Maksimenko, A.; Harrisson, S.; Desmaële, D.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201253, 19

[16] Functionalized Polymeric Nanocapsules of Perfluorooctyl Bromide.Diou, O.; Tsapis, N.; Delplace, V.; Nicolas, J.; Mackiewicz, N.; Robic, C.; Giraudeau, C.; Valette, J.; Fattal, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201253, 412


2011

[15] Design of Innocuous Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Chenal, M.; Mura, S.; Harrisson, Couvreur, P.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201152, 419


2010

[14] Nanoparticles Against Alzheimer's Disease: PEG-PACA Nanoparticles are Able to Link the Aβ-Peptide and Influence its Aggregation Kinetics. Brambilla, D.; Verpillot, R.; Taverna, M.; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. J. Control. Rel. 2010148, e112


2008

[13] Site-Directed Conjugation of Clicked Glycopolymers To Form Glycoprotein Mimics. Haddleton, D. M., Mantovani, G.; Lindqvist, J.; Jones, M. W.; Brayden, D.; Ryan, S.; Randev, R.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 1089

[12] Nanostructured Latex Particles Directly Obtained by Nitroxide-Mediated Emulsion Polymerization. Nicolas, J.; Ruzette, A.-V.; Charleux, B.; Magnet, S.; Gérard, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 205

[11] Toward the Synthesis of Clickable, Stealth Nanoparticles Based on Poly(alkyl cyanoacrylate). Nicolas, J.; Borretto, E.; Desmaële, D.; Andrieux, K.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 488

[10] Nitroxide-Mediated Controlled Free-Radical Polymerization of Poly(ethylene Glycol)-Based Monomers. Nicolas, J.; Couvreur, P.; Charleux, B. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 215


2006

[9] Fluorescently Tagged Bioconjugates from Living Radical Polymerization Using Protein Macroinitiators. San Miguel, V.; Nicolas, J.; Mantovani, G.; Haddleton, D. M. PMSE Prepr. (Am. Chem. Soc., Div. Polym. Mater. Sci. Eng.) 200695, 1064

[8] Nanoparticles Synthesized by Novel Nitroxide-Mediated Emulsion Polymerization Processes. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200647, 903

[7] Bioconjugation onto a Biological Surface Using Fluorescent Polymers Synthesized by Living Radical Polymerization. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200647, 15

[6] Strong Improvement of Nitroxide-Mediated Polymerizations of Methyl Methacrylate by a Copolymerization Approach: Polymer Synthesis and Characterizations. Nicolas, J.; Mueller, L.; Belleney, J.; Charleux, B. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006


2005

[5] Polymerization in Aqueous Dispersed Media Stabilized by Polyelectrolyte Copolymers. Delaittre, G.; Houillot, L.; Lefay, C.; Manguian, M.; Nicolas, J.; Chassenieux, C.; Save, M.; Charleux, B. 2nd Workshop of the Young European Scientists (YES 2005), Krakow, Poland, September 13-18, 2005, P_056[2005]

[4] Strong Improvement of Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate via a Copolymerization Approach. Nicolas, J.; Charleux, B.; Guerret, O. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200546, 403

[3] Use of a Novel Class of SG1-Based Water-Soluble Dialkoxyamine in Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200546, 484


2004

[2] Water-Soluble Alkoxyamine: Application as New Initiator in Aqueous Dispersed Systems. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1027

[1] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization with a Novel SG1-Based Water-Soluble Alkoxyamine. Nicolas, J.; Delaittre, G.; Lefay, C.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1054

Oral communications


International oral communications


2017

[39] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. International Conference On Nanomedicine And Nanobiotechnology (ICONAN) 2017, Barcelona, Spain, September 25.-27, 2017. [Invited]

[38] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. 252nd ACS National Meeting, Washington, DC, United States, August 20-24, 2017. [Invited]

[37] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. Advanced Polymers via Macromolecular Engineering (APME) 2017 congress, Ghent, Belgium, May 21-25, 2017. [Invited]


2016

[36] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 45th French Polymer Society (GFP) Meeting, Marseille, France, November 15-18, 2016. [Invited]

[35] Comb-like PEG-based Vinyl Copolymers for Biomedical Applications. Nicolas, J. 252nd ACS National Meeting, Philadelphia, PA, United States, August 21-25, 2016. [Invited]

[34] Vinyl Polymers for Biomedical Applications. Nicolas, J. Warwick Polymer Conference 2016, University of Warwick, Coventry, U.K., July 11-14, 2016. [Invited]

[33] Degradable PEG-Based Materials by Nitroxide-Mediated Radical Ring-Opening Copolymerization. Nicolas, J. Belgian Polymer Group annual meeting 2016, Hasselt, Belgium, 23-24 May, 2016. [Invited]

[32] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, Glasgow, UK, 4-7 April, 2016. [Invited]

[31] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 11th International Conference and Workshop on Biological Barriers, Helmotz-Institute for Pharmaceutical Research and Saarland University, Saarbrücken, Germany, 7-9 March, 2016. [Invited]


2015

[30] Nitroxide-Mediated Radical Ring-Opening Copolymerization: A Single Cyclic Ketene Acetal Comonomer to Control the Polymerization of Methacrylates and to Confer Degradability. Delplace, V.; Harrisson, S.; Guillaneuf, Y.; Gigmes, D.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015. [Invited]

[29] Conjugation and Bioconjugation from α-Functional Polymers Obtained by Nitroxide-Mediated Polymerization (NMP) Initiated by N-Hydroxysuccinimidyl- or Azlactone-Functionalized Alkoxyamines. Delplace, V.; Harrisson, S.; Guillaneuf, Y.; Pascual, S.; Fontaine, L.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015

[28] The Drug-Initiated Method: a Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles. Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015

[27] Advanced Polymer Nanoparticles For Efficient Drug Delivery. Nicolas, J. Applied Nanotechnology and Nanoscience International Conference (ANNIC 2015), Paris, France, 5-7 November, 2015. [Plenary]

[26] The Drug-Initiated Method: A Convenient Way for the Synthesis of Efficient Anticancer Polymer Prodrug Nanoparticles. Nicolas, J. International Symposium on Amphiphilic Polymers Networks, Gels and Membranes (APNGM15), Budapest, Hungary, 30 August–2 September, 2015. [Invited]


2014

[25] Advanced Polymer Nanoparticles for Drug Delivery. Nicolas, J. 4th Zing Polymer Chemistry Conference, Cancún, Mexico, December 10-13 2014. [Invited]

[24] Novel Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014. [Invited]

[23] Novel Multifunctional Polymer Nanoparticles for Active Targeting in Drug Delivery: Application to Cancer and Alzheimer's Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Andrieux, K.; Couvreur, P. 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014

[22] Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Nicolas, J.; Mackiewicz, N.; Handké, N.; Lakkiredy, H. R.; Bazile, D.; Couvreur, P. European Polymer Conference (EUPOC), Precision Polymers: Synthesis, Folding and Function, Gargnano, Italy, May 25-29, 2014


2013

[21] Novel Polyisoprenoid Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 3rd Conference on “Innovation in Drug Delivery: Advances in Local Drug Delivery”, Pisa, Italy, September 22-25, 2013

[20] Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Harrisson, S.; Nicolas, J.; Maksimenko, A.; Mougin, J.; Couvreur, P. European Polymer Federation (EPF) congress, Pisa, Italy, June 16-21, 2013


2012

[19] Gemcitabine-Polyisoprenoid Nanoparticles for Cancer Therapy. Nicolas, J.; Bui-Duc, T.; Maksimenko, A.; Harrisson, S.; Desmaële, D.; Couvreur, P. 244th ACS National Meeting, Philadelphia, PA, United States, August 19-23, 2012. [Invited]

[18] Dual Active Targeting Using a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Salvati, E.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. Macro Group UK International Conference on Polymer Synthesis, University of Warwick, U.K., July 9-12, 2012. [Invited]

[17] Poly(alkyl cyanoacrylate) Nanoparticles as a versatile Platform against Cancer and Alzheimer’s disease. Nicolas, J. 3rd International Congress Nanotechnology in Medicine & Biology (BioNanoMed), Krems, Austria, March 1-2, 2012. [Invited]


2011

[16] Design of Innocuous and Functional Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Nicolas, J.; Chenal, M.; Mura, S.; Harrisson, S.; Couvreur, P. 6th Spin Conference, Marseille, France, September 26-29, 2011

[15] Design of Innocuous Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Chenal, M.; Mura, S.; Harrisson, S.; Couvreur, P.; Nicolas, J. 242nd ACS National Meeting, Denver, CO, United States, August 28 - September 1, 2011. [Invited]

[14] Advanced Poly(alkyl cyanoacrylate) Nanoparticles for Cell Imaging and Against Alzheimer's Disease. Nicolas, J.; Brambilla, D.; Le Droumaguet, B.; Verpillot, R.; Taverna, M.; Gobbi, M.; Salmona, M.; Couvreur, P.; Andrieux, K.. Sydney 2011 International Nanomedicine Conference, Coogee Beach, Australia, July 14-16, 2011. [Invited]

[13] Advanced Poly(alkyl cyanoacrylate) Nanoparticle for Cell Imaging and Against Alzheimer's Disease.Nicolas, J. EuroNanoForum, Budapest, Hungary, May 30 - June 1, 2011


2010

[12] Advanced Poly(alkyl cyanoacrylate) Nanoparticles As Promising Therapeutic Agents for Alzheimer's Disease And Intracellular Trafficking. Brambilla, D.; Nicolas, J.; Verpillot, R.; Le Droumaguet, B.; Taverna, M.; Gobbi, M.; Canovi, M.; Couvreur, P.; Andrieux, K. 43rd MACRO IUPAC World Polymer Congress, Glasgow, UK, July 11-17, 2010

[11] Novel Materials From Nitroxide-Mediated Polymerization of Methacrylic Esters. Nicolas, J.; Brusseau, S.; Dire, C.; Couvreur, L.; Magnet, S.; Charleux, B. 43rd MACRO IUPAC World Polymer Congress, Glasgow, UK, July 11-17, 2010


2009

[10] Advanced Poly(alkyl cyanoacrylate) Nanoparticles for Drug Delivery Purposes. Nicolas, J.; Le Droumaguet, B.; Brambilla, D; Andrieux, K.; Couvreur, P. 11th Pacific Polymer Conference, Cairns, Australia, December 6-10, 2009. [Invited]

[9] Nitroxide-Mediated Controlled Radical Copolymerization and its Application to Methacrylate Monomers. Charleux, B., Nicolas, J.; Dire, C.; Brusseau, S.; Magnet, S.; Couvreur, L. 11th Pacific Polymer Conference, Cairns, Australia, December 6-10, 2009

[8] Synthesis of Highly Functionalized Nanoparticles Based on Poly(alkyl cyanoacrylate) by Means of Click Chemistry. Le Droumaguet, B.; Bensaid, F.; Roisin, J.; Andrieux, K.; Couvreur, P.; Nicolas, J. 17th International Symposium on Microencapsulation, Nagoya, Japan, September 29 - October 1, 2009

[7] Nanoparticles For Therapy of Alzheimer's Disease: Ability of PEGylated Poly(alkyl cyanoacrylate) Nanoparticles to Link to the Aβ Peptide 1-42 and to Influence its Aggregation Kinetics. Brambilla, D.; Verpillot, R.; Nicolas, J.; Taverna, M.; Couvreur, P.; Andrieux, K. 17th International Symposium on Microencapsulation, Nagoya, Japan, September 29 - October 1, 2009


2008

[6] Nanostructured Latex Particles Directly Obtained by Nitroxide-Mediated Emulsion Polymerization. Nicolas, J.; Ruzette, A.-V.; Charleux, B.; Magnet, S.; Gérard, P. 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008. [Invited]


2006

[5] Fluorescently Tagged Bioconjugates from Living Radical Polymerization Using Protein Macroinitiators. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[4] Nanoparticles Synthesized by Novel Nitroxide-Mediated Emulsion Polymerization Processes Nicolas, J.; Charleux, B.; Magnet, S. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[3] Bioconjugation onto a Biological Surface Using Fluorescent Polymers Synthesized by Living Radical Polymerization Nicolas, J.; Haddleton, D. M., Khoshdel, E. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[2] Use of Novel SG1-Based Water-Soluble Alkoxyamines in Nitroxide-Mediated Emulsion Polymerization Processes. Nicolas, J.; Charleux, B.; Magnet, S. Macro Group UK International Conference on Polymer Synthesis, University of Warwick, U.K., August 31 - September 1, 2006


2004

[1] Nitroxide-Mediated Controlled Free-Radical Polymerization in Aqueous Dispersed Media Using a SG1-Based Water-Soluble Alkoxyamine Initiator. Nicolas, J.; Charleux, B.; Magnet, S.; Guerret, O. International Symposium on Polymers in Dispersed Media (PDM), ENS, Lyon, France, April 4-8, 2004

 

National oral communications


2017

[8] Vinyl Polymers for Biomedical Applications. Nicolas, J. 45ème Journées d'Etudes des Polymères (JEPO), Gravelines, France, October 1-6, 2017. [Invited]


2016

[7] Polymer Nanoparticles for Biomedical Applications. Nicolas, J. 7ème journée GFP-IdF, "Polymères fonctionnels : de la chimie aux propriétés", ICPME, Université Paris-Est, Thiais, July 8, 2016. [Invited]


2015

[6] The Drug-Initiated Method: A New Route to More Potent Nanoparticles for Anticancer Therapy. Harrisson, S.; Maksimenko, A.; Bui, D. T.; Couvreur, P.; Nicolas, J. 2015 French Chemical Society meeting SCF'15, Lille, France, July 7-9, 2015.


2013

[5] Novel Polyisoprenoid Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 30ème Réunion du Club Emulsion, ENSCM, Montpellier, France, September 26-27, 2013


2012

[4] Utilisation des Nanoparticules de Polymère dans le Domaine du Ciblage. Nicolas, J. Journée scientifique de l’ICMPE: Santé et Interface avec le Vivant, Université Paris-Est, September 11, 2012. [Invited]

[3] Advanced Poly(Alkyl Cyanoacrylate) Nanoparticles for Specific Targeting and Imaging Purposes. Nicolas, J. CopAmphi 2012. Copolymères amphiphiles : synthèse, organisation, applications. Toulouse, France, June 5-7, 2012. [Invited]


2010

[2] Nanoparticules de Poly(alkyl cyanoacrylate) : Fonctionnalisation, Imagerie Intracellulaire et Interactions avec le Peptide Amyloïde Aβ. Nicolas, J. 23ème Colloque du Biotechnocentre, Tour, France, 21-22 Octobre, 2010. [Invited]


2004

[1] Polymérisation Radicalaire Contrôlée en Milieux Aqueux Dispersés par les Nitroxides - Utilisation d'une Alcoxyamine Hydrosoluble à Base SG1. Nicolas, J.; Charleux, B.; Magnet, S.; Guerret, O. 32ème Journées d'Etudes des Polymères (JEPO), La Brosse Montceaux, France, September 19-24, 2004

 

Invited seminars


2017

[13] Vinyl Polymers for Biomedical Applications. Nicolas, J. Conférences et Séminaires de l'ESPCI, ESPCI, Paris, France, March 24, 2017

[12] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. Minisymposium - Polymers for Medicine, Institute of Materials (IMX), EPFL, Lausanne, Switzerland, March 17, 2017


2016

[11] Vinyl Polymers for Biomedical Applications. Nicolas, J. Macromolecular Architectures (MacroArc) Research Team, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, January 27, 2016

[10] Advanced Polymer Nanoparticles Against Cancer and the Alzheimer's Disease. Nicolas, J. Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, January 26, 2016


2015

[9] Design of Polymer Nanoparticles Against Cancer and the Alzheimer's Disease. Nicolas, J. Institut Charles Sadron (ICS), Strasbourg, France, February 3, 2015


2014

[8] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Département de Chimie Moléculaire, Université Joseph Fourier, Grenoble, May 22, 2014

[7] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Institut de Chimie et des Matériaux Paris-Est, UMR CNRS 7182, Université Paris-Est, Paris, May 13, 2014

[6] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Laboratoire de Chimie des Polymères, Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie, Paris, April 4, 2014


2013

[5] Polymeric Nanoparticles for Drug Delivery and Targeting Purposes. Nicolas, J. Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Saclay, September 17, 2013

[4] Polymeric Nanoparticles for Drug Delivery and Targeting Purposes. Nicolas, J. Winter School, NAMDIATREAM European project, Villars‐sur‐Ollon, Switzerland, March 3-6, 2013


2012

[3] Nitroxide-Mediated Polymerization: From Kinetics to Biomaterials. Nicolas, J. UCO2M, UMR CNRS 6011, Université du Maine, April 10, 2012


2011

[2] Controlled/Living Radical Polymerization and its Application to the design of Protein/Peptide-Polymer Bioconjugates. Nicolas, J. PeptiSyntha, Solvay, Bruxelles, December 19, 2011

[1] NMP is Coming Home with Some Stories to Tell. Nicolas, J. CMAD, University of New South Wales, Sydney, Australia, July 13, 2011

Vacancies

No position available at the moment. Please check back later.

Read more

Covers






Twitter