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2018

[88] Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters. Guégain, E.; Michel, J.-P.; Boissenot, T.; Nicolas, J.* Macromolecules 2018, in press. DOI: 10.1021/acs.macromol.7b02655

 

[87] Self-Stabilized, Hydrophobic or PEGylated Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy. Bao, Y.; Guégain, E.; Mougin, J.; Nicolas, J.* Polym. Chem. 2018, in press. DOI: 10.1039/c7py01918a

 

[86] Antibody-Functionalized Polymer Nanoparticle Leading to Memory Recovery in Alzheimer’s Disease-like Transgenic Mouse Model.Carradori, D.; Balducci, C.; Re, F.;* Brambilla, D.; Le Droumaguet, B.; Flores, O.; Gaudin¸ A.; Mura, S.; Forloni, G.; Ordoñez-Gutierrez, L.; Wandosell, F.; Masserini, M.; Couvreur, P.; Nicolas, J.;* Andrieux, K. Nanomedicine NBM 2018, in press. DOI: 10.1016/j.nano.2017.12.006

 

[85] Telechelic Polymers from Reversible-Deactivation Radical Polymerization for Biomedical Applications. Vinciguerra, D.; Tran, J.; Nicolas, J.;* Chem. Commun. 2018, 54, 228. DOI: 10.1039/c7cc08544c


2017

[84] Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters. Tardy, A.; Honoré, J.-C.; Tran, J.; Siri, D.; Delplace, V.; Bataille, I.; Letourneur, D.; Perrier, J.; Nicoletti, S.; Maresca, M.; Lefay, C.; Gigmes, D.; Nicolas, J.;* Guillaneuf, Y.* Angew. Chem., Int. Ed. 2017, 56, 16515. DOI: 10.1002/anie.201707043

 

[83] Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units. Hill, M. R.; Guégain, E.; Tran, J.; Figg, C. A.; Turner, A. C.; Nicolas, J.*, Sumerlin, B. S.* ACS Macro Lett. 2017, 6, 1071. DOI: 10.1021/acsmacrolett.7b00572

 

[82] Structure-Cytotoxicity Relationship of Drug-Initiated Polymer Prodrug Nanoparticles. Bao.; Y.; Nicolas, J.* Polym. Chem. 2017, 8, 5174. DOI: 10.1039/c7py00536a

 

[81] Fluorescent Polymer Prodrug Nanoparticles with Aggregation-Induced Emission (AIE) Properties from Nitroxide-Mediated Polymerization. Bao.; Y.; Guégain, E.; Nicolas, V.; Nicolas, J.* Chem. Commun. 2017, 53, 4489. DOI: 10.1039/c6cc09052d

 

[80] A Comprehensive Kinetic Study of the Conventional Free-Radical Polymerization of Seven-Membered Cyclic Ketene Acetals. Tardy, A.; Honoré, J.-C.; Siri, D.; Nicolas, J.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.* Polym. Chem. 2017, 8, 5139. DOI: 10.1039/c7py00337d

 

[79] Polymer Nanoparticles for the Delivery of Anticancer Drugs. Nicolas, J.;* Couvreur. P. Med./Sci. 2017, 33, 11. DOI: 10.1051/medsci/20173301003

 

[78] Radical Ring-Opening Polymerization: Scope, Limitations and Application to (Bio)Degradable Materials. Tardy, A.; Nicolas, J.; Gigmes, D.; Lefay, C.;* Guillaneuf, Y.* Chem. Rev. 2017, 117, 1319. DOI: 10.1021/acs.chemrev.6b00319


2016

[77] Pulmonary Surfactant Protein A: A Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages. Ruge, C. A.; Hillaireau, H.; Grabowski, N.; Beck-Broichsitter, M.; Cañadas, O.; Tsapis, N.; Casals, C.; Nicolas, J.; Fattal, E.* Mol. Pharm. 2016, 13, 4168. DOI: 10.1021/acs.molpharmaceut.6b00773


[76] Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tuneable Drug Delivery Properties. Bao, Y.; Boissenot, T.; Guégain, E.; Desmaële, D.; Mura, S.; Couvreur, P.; Nicolas, J.* Chem. Mater. 2016, 28, 6266. DOI: 10.1021/acs.chemmater.6b02502


[75] Efficient Synthesis of 2-Methylene-4-Phenyl-1,3-Dioxolane, a Cyclic Ketene Acetal for Controlling the NMP of Methyl Methacrylate and Conferring Tunable Degradability. Tran, J.; Guégain, E.; Ibrahim, N.; Harrisson, S.; Nicolas, J.* Polym. Chem. 2016, 7, 4427. DOI: 10.1039/c6py00778c


[74] Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery. Nicolas, J.* Chem. Mater. 2016, 28, 1591. DOI: 10.1021/acs.chemmater.5b04281 (invited Perspective article)


[73] Nitroxide-Mediated Polymerization of Vinyl Chloride at Low Temperature: Kinetic and Computational Studies. Abreu, C. M. R.; Mendonça, P. V.; Serra, A. C.; Noble, B. B.; Guliashvili, T.;* Nicolas, J.;* Coote, M. L.;* Coelho, J. F. J.* Macromolecules 2016, 49, 490. DOI: 10.1021/acs.macromol.5b02017


[72] Cyclopentyl Methyl Ether as a Green Solvent for Reversible-Addition Fragmentation Chain Transfer and Nitroxide-Mediated Polymerizations. Abreu, C. M. R.; Maximiano, P.; Guliashvili, T.; Nicolas, J.;* Serra, A. C.; Coelho, J. F. J.* RSC Advances 2016, 6, 7495. DOI: 10.1039/c5ra21975b


2015

[71] Degradable Vinyl Polymers for Biomedical Applications. Delplace, V.; Nicolas, J.* Nature Chem. 2015, 7, 771. DOI: 10.1038/nchem.2343


[70] A Ring to Rule Them All: A Cyclic Ketene Acetal Comonomer Controls the Nitroxide-Mediated Polymerization of Methacrylates and Confers Tunable Degradability. Delplace, V.; Guégain, E.; Harrisson, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Chem. Commun. 2015, 51, 12847. DOI: 10.1039/c5cc04610f


[69] Solvent Selection Causes Remarkable Shifts of the “Ouzo Region” for Poly(Lactide-co-Glycolide) Nanoparticles Prepared by Nanoprecipitation. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Nanoscale 2015, 7, 9215. DOI: 10.1039/c5nr01695a


[68] Design Attributes of Long-Circulating Polymeric Drug Delivery Vehicles. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Eur. J. Pharm. Biopharm. 2015, 97, Part B, 304. DOI: 10.1016/j.ejpb.2015.03.033


[67] One-Step Synthesis of Azlactone-Functionalized SG1-Based Alkoxyamine for Nitroxide-Mediated Polymerization and Bioconjugation. Delplace, S.; Harrisson, S.; Ho, H. T.; Tardy, A.; Guillaneuf, Y.; Pascual, S.; Fontaine, L.; Nicolas, J.* Macromolecules 2015, 48, 2087. DOI: 10.1021/acs.macromol.5b00178


[66] On the Structure-Control Relationship of Amide-Functionalized SG1-Based Alkoxyamines for Nitroxide-Mediated Polymerization and Conjugation. Guégain, E.; Delplace, V.; Trimaille, T.; Gigmes, D.; Siri, D.; Marque, S.; Guillaneuf, Y.; Nicolas, J.* Polym. Chem. 2015, 6, 5693. DOI: 10.1039/c5py00283d. [Feature article in Polym. Chem. Emerging Investigator issue 2015]

 

[65] Nitroxide-Mediated Polymerization of Methacrylic Esters: Insights and Solutions to a Long Standing Problem. Guégain, E.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2015, 36, 1227. DOI: 10.1002/marc.201500042. [Cover]

 

[64] Lipid Prodrug Nanocarriers in Cancer Therapy. Mura, S.;* Bui, D. T., Couvreur, P.; Nicolas, J.* J. Control. Release 2015, 28, 25. DOI: 10.1016/j.jconrel.2015.01.021

 

2014

[63] In the (Very) Long Run We Are All Dead: Activation and Termination in SET-LRP/SARA-ATRP. Harrisson, S.;* Nicolas, J. ACS Macro Lett. 2014, 3, 643. DOI: 10.1021/mz500305j


[62] Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method. Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur P.; Nicolas, J.* Chem. Mater. 2014, 26, 3606. DOI: 10.1021/cm501500k


[61] Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Mackiewicz, N.; Nicolas, J.;* Handké, N.; Noiray, M.; Mougin, J.; Daveu, C.; Reddy, L. H.; Bazile, D.; Couvreur, P. Chem. Mater. 2014, 26, 1834. DOI: 10.1021/cm403822w


[60] RGD Decoration of PEGylated Polyester Nanocapsules of Perfluorooctyl Bromide for Tumor Imaging: Influence of Pre- or Post-Functionalization on Capsule Morphology. Diou, O.; Fattal, E.; Delplace, V.; Mackiewicz, N.; Nicolas, J.; Mériaux, S.; Valette, J.; Robic, C.; Tsapis, N.* Eur. J. Pharm. Biopharm. 201487, 170. DOI: 10.1016/j.ejpb.2013.12.003


[59] Nitroxide-Mediated Radical Ring-Opening Copolymerization: Chain-End Investigation and Block Copolymer Synthesis. Delplace, V.; Harrisson, S.; Tardy, A.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2014, 35, 484. DOI: 10.1002/marc.201300809


[58] Recent Trends in the Design of Anticancer Polymer Prodrug Nanocarriers. Delplace, V.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2014, 5, 1529. DOI: 10.1039/c3py01384g


[57] Multifunctional Squalene-Based Prodrug Nanoparticles for Targeted Cancer Therapy. Bui, D. T.; Nicolas, J.;* Maksimenko, A.; Desmaële, D.; Couvreur, P. Chem. Commun. 2014, 50, 5336. DOI: 10.1039/c3cc47427e. [Feature article in Chem. Commun. Emerging Investigator issue 2014]



2013

[56] Degradable PEG-Based and Comblike Copolymers by Nitroxide-Mediated Radical Ring-Opening Polymerization. Delplace, V.; Tardy, A.; Harrisson, S.; Mura, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Biomacromolecules 2013, 14, 3769. DOI: 10.1021/bm401157g


[55] Stimuli-Responsive Nanocarriers for Drug Delivery. Mura, S.; Nicolas, J.; Couvreur, P.* Nature Mater. 2013, 12, 991. DOI: 10.1038/nmat3776


[54] Polymer Prodrug Nanoparticles Based on Naturally Occurring Isoprenoid for Anticancer Therapy. Bui, D. T.; Maksimenko, A.; Desmaële, D.; Harrisson, S.; Vauthier, C.; Couvreur, P.; Nicolas, J.* Biomacromolecules 2013, 14, 2837. DOI: 10.1021/bm400657g


[53] Scope and Limitations of the Nitroxide-Mediated Radical Ring Opening Polymerization of Cyclic Ketene Acetals. Tardy, A.; Delplace, V.; Siri, D.; Lefay, C.; Harrisson, S.; de Fatima Albergaria Pereira, B.; Charles, L.; Gigmes, D.;* Nicolas, J.; Guillaneuf, Y.* Polym. Chem. 2013, 4, 4776. DOI: 10.1039/c3py00719g. [Paper of the week]


[52] Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one ß-Carboline Series and Study of Phenotypic Properties on C. elegans. Cebrián-Torrejón, G.; Mackiewicz, N.; Vázquez-Manrique, R.; Fournet, A.; Figadère, B.; Nicolas, J.; Poupon, E.* Eur. J. Org. Chem. 2013, 5821. DOI: 10.1002/ejoc.201300770. [Cover]


[51] Effect of Nanoparticles Binding Beta-Amyloid Peptide on Nitric Oxide Production by Cultured Endothelial Cells and Macrophages. Orlando, F.; Re, F.; Sesana, S.; Rivolta, I.; Panariti, A.; Brambilla, D.; Nicolas, J.; Couvreur, P.; Andrieux, K.; Masserini, M.; Cazzaniga, E. Int. J. Nanomed. 2013, 8, 1335. DOI: 10.2147/ijn.s40297


[50] Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Harrisson, S.; Nicolas, J.;* Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Angew. Chem., Int. Ed. 2013, 52, 1678. DOI: 10.1002/anie.201207297


[49] Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate). Babinot, J.; Le Droumaguet, B.; Renard, E.; Guigner, J.-M.; Mura, S.; Nicolas, J.; Couvreur, P.; Langlois, V.* Macromol. Rapid Commun. 2013, 34, 362. DOI: 10.1002/marc.201200692


[48] Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanoparticles for Drug Delivery. Nicolas, J.;* Mura, S.; Brambilla, D.; Mackiewicz, N.; Couvreur, P. Chem. Soc. Rev. 2013, 42, 1147. DOI: 10.1039/c2cs35265f


[47] Nitroxide-Mediated Polymerization. Nicolas, J.;* Guillaneuf, Y.;* Lefay, C.; Bertin, D.; Gigmes, D.; Charleux, B. Prog. Polym. Sci. 2013, 38, 63. DOI: 10.1016/j.progpolymsci.2012.06.002



2012

[46] Comproportionation versus Disproportionation in the Initiation step of Cu(0)-Mediated Living Radical Polymerization. Harrisson, S.;* Couvreur, P.; Nicolas, J.* Macromolecules 2012, 45, 7388. DOI: 10.1021/ma301034t


[45] PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Towards Engineering of Functional Nanomedicines for Alzheimer’s Disease. Brambilla, D.; Verpillot, R.; Le Droumaguet, B.; Nicolas, J.; Taverna, M.; Kóna, J.; Lettiero, B.; Hashemi, S. H.; De Kimpe, L.; Canovi, M.; Gobbi, M.; Nicolas, V.; Scheper, W.; Moghimi, S. M.; Tvaroška, I.; Couvreur, P.; Andrieux, K.* ACS Nano 2012, 6, 5897. DOI: 10.1021/nn300489k


[44] Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. Le Droumaguet, B.; Nicolas, J.;* Brambilla, D.; Mura, S.; Maksimenko, A.; De Kimpe, L.; Salvati, E.; Zona, C.; Airoldi, C.; Canovi, M.; Gobbi, M.; Noiray, M.; La Ferla, B.; Nicotra, F.; Scheper, W.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. ACS Nano 2012, 6, 5866. DOI: 10.1021/nn3004372


[43] Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications. Harivardhan Reddy, L.; Arias, J. L.; Nicolas, J.; Couvreur, P.* Chem. Rev. 2012, 112, 5818. DOI: 10.1021/cr300068p


[42] Use of Solvent Effects to Improve Control over Nitroxide-Mediated Polymerization of Isoprene. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromol. Rapid Commun. 2012, 33, 805. DOI: 10.1002/marc.201100866. [Feature article in Macromol. Rapid Commun. Polymer Science: The Next Generation issue]


[41] NIR-Labelling of PLGA Nanoparticles for In Vivo Imaging. Reul, R.; Tsapis, N.*; Hillaireau, H.; Sancey, L.; Mura, S.; Recher, M.; Nicolas, J.; Coll, J.-L.; Fattal, E. Polym. Chem. 2012, 3, 694. DOI: 10.1039/c2py00520d



2011

[40] SG1 Nitroxide-Mediated Polymerization of Isoprene: Alkoxyamine Structure/Control Relationship and a,w-Chain-End Functionalization. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromolecules 2011, 44, 9230. DOI: 10.1021/ma202078q


[39] Biodegradable Nanoparticles Meet the Bronchial Airway Barrier: How Surface Properties Affect Their Interaction with Mucus and Epithelial Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Kerdine-Römer, S.; Le Droumaguet, B.; Deloménie, C.; Nicolas, V.; Pallardy, M.; Tsapis, N.; Fattal, E.* Biomacromolecules 2011, 12, 4136 . DOI: 10.1021/bm201226x


[38] Influence of Surface Charge on the Potential Toxicity of PLGA Nanoparticles Towards Calu-3 Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Le Droumaguet, B.; Geutin, C.; Zanna, S.; Tsapis, N.; Fattal, E.* Int. J. Nanomed. 2011, 6, 2591. DOI: 10.2147/ijn.s24552


[37] Colloidal Properties of Biodegradable Nanoparticles Influence Interaction with Amyloid-ß Peptide. Brambilla, D.; Souguir, H., Nicolas, J.;* Mackiewicz, N.; Verpillot, R.; Le Droumaguet, B.; Taverna, M.; Couvreur, P.; Andrieux, K. J. Biotechnol. 2011, 156, 338. DOI: 10.1016/j.jbiotec.2011.07.020


[36] Quantum Dot-Loaded PEGylated Poly(alkyl cyanoacrylate) Nanoparticles for In Vitro and In Vivo Imaging. Nicolas, J.;* Brambilla, D.; Carion, O.; Pons, T.; Maksimovic, I.; Larquet, E.; Le Droumaguet, B.; Andrieux, K.; Dubertret, B.; Couvreur, P. Soft Matter 2011, 7, 6187. DOI: 10.1039/c1sm05529a


[35] Simple and Efficient Copper Metal-Mediated Synthesis of Alkoxyamines. Harrisson, S.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1853. DOI: 10.1039/c1py00131k


[34] Nanotechnologies and Alzheimer’s Disease: Diagnosis, Therapy and Safety Issues. Brambilla, D.; Le Droumaguet, B.; Nicolas, J.;* Hashemi, S. H.; Wu, L.-P.; Moghimi, S. M.; Couvreur, P.; Andrieux, K. Nanomedicine: NBM 2011, 7, 521. DOI: 10.1016/j.nano.2011.03.008


[33] First Peptide/Protein PEGylation with Functional Polymers Designed by Nitroxide-Mediated Polymerization. Chenal, M.; Boursier, C.; Guillaneuf, Y.; Taverna, M.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1523. DOI: 10.1039/c1py00028d


[32] Selegiline-Functionalized, PEGylated Poly(alkyl cyanoacrylate) Nanoparticles: Investigation of Interaction with Amyloid-ß Peptide and Surface Reorganization. Le Droumaguet, B.; Souguir, H.; Brambilla, D.; Verpillot, R.; Nicolas, J.;* Taverna, M.; Couvreur, P.; Andrieux, K.* Int. J. Pharm. 2011, 416, 453. DOI: 10.1016/j.ijpharm.2011.01.015



2010

[31] A New Method Based on Capillary Electrophoresis with Laser-Induced Fluorescence Detection (CE-LIF) to Monitor Interaction Between Nanoparticles and the Amyloid-ß Peptide. Brambilla, D.; Verpillot, R.; Taverna, M.*; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. Anal. Chem. 2010, 82, 10083. DOI: 10.1021/ac102045x


[30] Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions. Chenal, M.; Mura, S.; Marchal, C.; Gigmes, D.; Charleux, B.; Fattal, E.; Couvreur, P.; Nicolas, J.* Macromolecules 2010, 43, 9291. DOI: 10.1021/ma101880m


[29] PEGylation and Preliminary Biocompatibility Evaluation of Magnetite-Silica Nanocomposites Obtained by High Energy Ball Milling. Pilloni, M.; Nicolas, J.;* Marsaud, V.; Bouchemal, K.; Frongia, F.; Scano, A.; Ennas, G.; Dubernet, C. Int. J. Pharm. 2010, 401, 103. DOI: 10.1016/j.ijpharm.2010.09.010


[28] Design of Fluorescently Tagged Poly(alkyl cyanoacrylate) Nanoparticles for Human Brain Endothelial Cell Imaging. Brambilla, D.; Nicolas, J.;* Le Droumaguet, B.; Andrieux, K.*; Marsaud, V.; Couraud, P.-O.; Couvreur, P. Chem. Commun. 2010, 46, 2602. DOI: 10.1039/b924028d


[27] Recent Advances in the Design of Bioconjugates from Controlled/Living Radical Polymerization. Le Droumaguet, B.; Nicolas, J.* Polym. Chem. 2010, 1, 563. DOI: 10.1039/b9py00363k. [Cover]


[26] A Minimal Amount of Acrylonitrile Turns the Nitroxide-Mediated Polymerization of Methyl Methacrylate Into an Almost Ideal Controlled/Living System. Nicolas, J.;* Brusseau, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 34. DOI: 10.1002/pola.23749



2009

[25] Formulation of Didanosine Prodrugs into PEGylated Poly(alkyl cyanoacrylate) Nanoparticles and Uptake by Brain Endothelial Cells. Pierson, L.-A; Nicolas, J.; Lalanne, M.; Brambilla, D.; Marsaud, V.; Nicolas, V.; Ball, R.; Stanimirovic, D.; Couvreur, P.; Andrieux, K.* J. Nanoneurosci. 2009, 1, 174. DOI: 10.1166/jns.2009.1007


[24] Application of Thermal Analysis to the Study of Lipidic Prodrug Incorporation Into Nanocarriers. Bourgeois, J.; Pierson, L.-A.; Nicolas, J.; Lalanne, M.; Couvreur, P.; Andrieux, K.* J. Therm. Anal. Cal. 2009, 98, 65. DOI: 10.1007/s10973-009-0350-7


[23] Comprehensive Modeling Study of Nitroxide-Mediated Controlled/Living Radical Copolymerization of Methyl Methacrylate with a Small Amount of Styrene. Nicolas, J.;* Mueller, L.; Dire, C.; Matyjaszewski, K.; Charleux, B.* Macromolecules 2009, 44, 4470. DOI: 10.1021/ma900515v


[22] Synthesis of Poly(alkyl cyanoacrylate)-Based Colloidal Nanomedicines. Nicolas, J.;* Couvreur, P. Wiley Interdiscipl. Rev. Nanomed. Nanobiotechnol. 2009, 1, 111. DOI: 10.1002/wnan.15



2008

[21] Novel PEGylated Nanoassemblies Made of Self-Assembled Squalenoyl Nucleoside Analogues. Bekkara-Aounallah, F.; Gref, R.*; Othman, M.; Reddy, H.; Pili, B.; Allain, V.; Bourgaux, C.; Hillaireau, H.; Lepêtre-Mouelhi, S.; Desmaële, D.; Nicolas, J.; Chafi, N.; Couvreur, P. Adv. Funct. Mater. 2008, 18, 3715. DOI: 10.1002/adfm.200800705


[20] Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry. Nicolas, J.;* Bensaid, F.; Desmaële, D.; Grogna, M.; Detrembleur, D.; Andrieux, K.; Couvreur, P. Macromolecules 2008, 41, 8418. DOI: 10.1021/ma8013349


[19] Beta-Hydrogen Transfer from Poly(methyl methacrylate) Propagating Radicals to the Nitroxide SG1: Analysis of the Chain-end and Determination of the Rate Constant. Dire, C.; Belleney, J.; Nicolas, J.; Bertin, D.; Magnet, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 6333. DOI: 10.1002/pola.22945


[18] Comblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical Polymerization. Nicolas, J.;* Couvreur, P.; Charleux, B. Macromolecules 2008, 41, 3758. DOI: 10.1021/ma800609b


[17] Separation of Complex Branched Polymers by Size-Exclusion Chromatography Probed with Multiple Detection. Gaborieau, M.; Nicolas, J.; Save, M.; Charleux, B.; Vairon, J.-P.; Gilbert, R. G.; Castignolles, P.* J. Chromatogr. A 2008, 1190, 215. DOI: 10.1016/j.chroma.2008.03.031



2007

[16] Site-Directed Conjugation of "Clicked" Glycopolymers to Form Glycoprotein Mimics: Binding to Mammalian Lectin and Induction of Immunological Function. Geng, J.; Mantovani, G.*; Tao, L.; Nicolas, J.; Chen, G.; Wallis, R.; Mitchell, D. A.; Johnson, B. R. G.; Evans, S. D.; Haddleton, D. M.* J. Am. Chem. Soc. 2007, 129, 15156. DOI: 10.1021/ja072999x


[15] Nanostructured Latex Particles Synthesized by Nitroxide-Mediated Controlled/Living Free-Radical Polymerization in Emulsion. Nicolas, J.;* Ruzette, A.-V.; Farcet, C.; Gérard, P.; Magnet, S.; Charleux, B.* Polymer 2007, 48, 7029. DOI: 10.1016/j.polymer.2007.09.039


[14] Water-Soluble SG1-Based Alkoxyamines: a Breakthrough in Controlled/Living Free-Radical Polymerization in Aqueous Dispersed Media. Charleux, B.*; Nicolas, J. Polymer 2007, 48, 5813. DOI: 10.1016/j.polymer.2007.07.031. [Cover]


[13] Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates. Nicolas, J.;* Mantovani, G.; Haddleton, D. M.* Macromol. Rapid Commun. 2007, 28, 1083. DOI: 10.1002/marc.200700112


[12] Bioconjugation onto Biological Surfaces with Fluorescently Labeled Polymers. Nicolas, J.; Khoshdel, E.; Haddleton, D. M.* Chem. Commun. 2007, 1722. DOI: 10.1039/b617596a



2006

[11] Living Character of Polymer Chains Prepared via Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate in the Presence of a Small Amount of Styrene at Low Temperature. Nicolas, J.; Dire, C.; Mueller, L.; Belleney, J.; Charleux, B.*; Marque, S. R. A.; Bertin, D.; Magnet, S.; Couvreur, L. Macromolecules 2006, 39, 8274. DOI: 10.1021/ma061380x


[10] Fluorescently Tagged Polymer Bioconjugates from Protein Derived Macroinitiators. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M.* Chem. Commun. 2006, 4697. DOI: 10.1039/b609935a


[9] Multistep and Semi-Batch Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization: A Significant Step Toward Conceivable Industrial Processes. Nicolas, J.; Charleux, B.*; Magnet, S. J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 4142. DOI: 10.1002/pola.21519


[8] Aqueous Suspension of Amphiphilic Diblock Copolymer Nanoparticles Prepared in Situ from a Water-Soluble Poly(sodium acrylate) Alkoxyamine Macroinitiator. Delaittre, G.; Nicolas, J.; Lefay, C.; Save,M.; Charleux, B.* Soft Matter 2006, 2, 223. DOI: 10.1039/b515267d



2005

[7] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization Using a Difunctional Water-Soluble Alkoxyamine Initiator. Toward the Control of Particle Size, Particle Size Distribution and the Synthesis of Triblock Copolymers. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2005, 38, 9963. DOI: 10.1021/ma0511999


[6] Miniemulsion Polymerization of Styrene using a pH-Responsive Cationic Diblock Copolymer and its Reactive Copolymer Counterpart as Stabilizers. Houillot, L.; Nicolas, J.; Save, M.*; Charleux, B.; Li, Y.; Armes, S. P. Langmuir 2005, 21, 6726. DOI: 10.1021/la050495b


[5] Theoretical Expression of the Average Activation-Deactivation Equilibrium Constant in Controlled/Living Free-Radical Copolymerization Operating via Reversible Termination. Application to a Strongly Improved Control in Nitroxide-Mediated Polymerization of Methyl Methacrylate. Charleux, B.*; Nicolas, J.; Guerret, O. Macromolecules 2005, 38, 5485. DOI: 10.1021/ma050087e


[4] Surfactant-Free Synthesis of Amphiphilic Diblock Copolymer Nanoparticles via Nitroxide-Mediated Controlled Free-Radical Polymerization. Delaittre, G.; Nicolas, J.; Lefay, C.; Save, M.; Charleux, B.* Chem. Commun. 2005, 614. DOI: 10.1039/b415959d



2004

[3] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization of Styrene and n-Butyl Acrylate Using a Water-Soluble Alkoxyamine. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Angew. Chem., Int. Ed. 2004, 43, 6186. DOI: 10.1002/anie.200460704


[2] Novel SG1-Based Water-Soluble Alkoxyamine for Nitroxide-Mediated Controlled Free-Radical Polymerization of Styrene and n-Butyl Acrylate in Miniemulsion. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2004, 37, 4453. DOI: 10.1021/ma049800a



2002

[1] Kinetic Study of Nitroxide-Mediated Controlled Free-Radical Polymerization of n-Butyl Acrylate in Aqueous Miniemulsion. Farcet, C.; Nicolas, J.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 4410. DOI: 10.1002/pola.10531


Editorials


2011

[1] Editorial. Fattal, E.;* Nicolas, J.; Tsapis, N. Int. J. Pharm. 2011, 416, 401. DOI: 10.1016/j.ijpharm.2011.05.018

Patents


2014

[5] Couvreur, P.; Nicolas, J.; Blin, T.; Chtourou, A.; Genevaz, N. Copolymers of Formula (I) and Uses. Patent WO 2015181504 (with LFB)


2012

[4] Bazile, D.; Couvreur, P.; Lakkireddy, H.; Nicolas, J. Functional PLA-PEG Copolymers, the Nanoparticles Thereof, their Preparation and Use for Targeted Drug Delivery and Imaging. Patent WO 2013127949 (with Sanofi)


2007

[3] Haddleton, D. M.; Khoshdel, E.; Nicolas, J. A Method for Derivatizing Hair with a Reactive Polyethylene Glycol. Patent WO 2008058989 (with Unilever)


2006

[2] Gérard, P.; Magnet, S.; Guerret, O.; Nicolas, J.; Charleux, B. Method for Preparing a Living Polymer Comprising Methacrylic and/or Methacrylate Units. Patent WO 2007057620 (with Arkema)


2004

[1] Charleux, B.; Guerret, O.; Magnet, S.; Nicolas, J. Method for Radical Emulsion Polymerization Using Hydrosoluble Alkoxyamines. Patent WO 2005082945 (with Arkema)

Book chapters


2016

[13] Bioconjugates and Biomaterials Prepared by Nitroxide-Mediated Polymerization. Harth, E. M.; Nicolas, J.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-1782620617


[12] Nitroxide-Mediated Polymerization of Methacrylic Esters: How to Circumvent a Long-Time Obstacle. Nicolas, J.; Guégain, E.; Guillaneuf, Y.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-1782620617

2015

[11] The Drug-Initiated Method: A Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles. Harrisson, S.; Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur, P.; Nicolas, J.* In Controlled Radical Polymerization: Materials; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 257-272. DOI: 10.1021/bk-2015-1188.ch016


[10] Kinetic Studies of Elementary Reactions in SET-LRP / SARA ATRP. Nicolas, J.; Perrier, S.; Harrisson, S.* In Controlled Radical Polymerization: Mechanisms; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 129-143. DOI: 10.1021/bk-2015-1187.ch007


2014

[9] Living Radical Polymerization: Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y. In Encyclopedia of Polymeric Nanomaterials; Kobayashi, S. and Mullen, K. Eds.; Springer: New York, 2014, 1-16. ISBN 978-3-642-29647-5


[8] Polymer-Protein/Peptide Bioconjugates. Wilson, P.; Nicolas, J.; Haddleton, D. M. In Chemistry of Organo-Hybrids: Synthesis and Characterization of Functional Nano-Objects; Lacôte, E.; Charleux, B.; Copéret, C. Eds.; Wiley-VCH, 2014, 465-502. ISBN: 978-1-118-37902-8


2013

[7] Polymeric Nanoparticles for Drug Delivery. Andrieux, K.; Nicolas, J.; Moine, L.; Barrat, G. In Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, Volume 2; Dumitriu, S.; Popa, V. Eds.; CRC Press, 2013, 123-151. ISBN: 978-1420094688


2012

[6] Targeted Delivery Using Biodegradable Polymeric Nanoparticles. Fattal, E.; Hillaireau, H.; Mura, S.; Nicolas, J.; Tsapis, N. In Fundamentals and Applications of Controlled Release Drug Delivery; Siepmann, J.; Siegel, R. A.; Rathbone, M. J. Eds.; Advances in Delivery Science and Technology Series; Controlled Release Society, Springer, 2012, 255-288. ISBN: 978-1461408802


[5] Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y.; Bertin, D.; Gigmes, D.; Charleux, B. In Polymer Science: A Comprehensive Reference; Matyjaszewski, K.; Möller, M. Eds.; Elsevier, 2012, 3, 277. ISBN: 978-0444533494


2011

[4] Poly(alkyl cyanoacrylate) Nanosystems. Nicolas, J.; Vauthier, C. In Intracellular Delivery: Fundamentals and Applications; Fundamental Biomedical Technologies; Prokop, A. Ed.; Springer, 2011, 225-250. ISBN: 978-9400712478


2010

[3] Controlled/Living Radical Polymerization in Aqueous Miniemulsion. Lefay, C.; Nicolas, J. In Miniemulsion Polymerization Technology; Mittal, V. Ed.; Scrivener Publishing: Salem, MA, 2010, 173-210. ISBN: 978-0470625965


2009

[2] Nitroxide-Mediated Controlled Free-Radical Copolymerization of Poly(ethylene glycol) Methyl Ether Methacrylate and Methacrylic Acid. Toward New Water-Soluble Macroinitiators. Dire, C.; Nicolas, J.; Brusseau, S.; Charleux, B.; Magnet, S.; Couvreur, L. In Controlled/Living Radical Polymerization: Progress in RAFT, NMP & OMRP; Matyjaszewski, K. Ed.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2009, Vol. 1024, 303-318. DOI: 10.1021/bk-2009-1024.ch020


2008

[1] Fluorescently Labeled Protein-Polymer Bioconjugates Using Protein Derived Macroinitiators from Living Radical Polymerization. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M. In Polymers for Biomedical Applications; Mahapatro, A.; Kulshrestha, A. S. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2008, Vol. 977, 78-94. DOI: 10.1021/bk-2008-0977.ch006

Proceedings


2014

[23] Novel Nanoparticles with In Vivo Anticancer Activity from Well-​Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-650

[22] Nitroxide-​Mediated Radical Ring-Opening Copolymerization: Towards the Design of Block Copolymers Comprising a Degradable Block. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-343

[21] Comproportionation, Activation, and Termination in SET LRP​/SARA ATRP. Harrisson, S.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-222

[20] Toward Radical Ring-​Opening Living Polymerization via NMP: End-​Chain Characterization, Livingness, and Control. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-17

[19] New Biodegradable PEG-​Based Copolymers Synthesized by Nitroxide-​Mediated Radical Ring-​Opening Polymerization, for Biomedical Applications. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-624

[18] Novel Multifunctional Polymer Nanoparticles for Active Targeting in Drug Delivery: Application to Cancer and Alzheimer's Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Andrieux, K.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, COLL-397


2012

[17] Gemcitabine-Polyisoprenoid Nanoparticles for Potential Application in Cancer Therapy. Nicolas, J.; Bui, D. T.; Maksimenko, A.; Harrisson, S.; Desmaële, D.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201253, 19

[16] Functionalized Polymeric Nanocapsules of Perfluorooctyl Bromide.Diou, O.; Tsapis, N.; Delplace, V.; Nicolas, J.; Mackiewicz, N.; Robic, C.; Giraudeau, C.; Valette, J.; Fattal, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201253, 412


2011

[15] Design of Innocuous Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Chenal, M.; Mura, S.; Harrisson, Couvreur, P.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 201152, 419


2010

[14] Nanoparticles Against Alzheimer's Disease: PEG-PACA Nanoparticles are Able to Link the Aβ-Peptide and Influence its Aggregation Kinetics. Brambilla, D.; Verpillot, R.; Taverna, M.; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. J. Control. Rel. 2010148, e112


2008

[13] Site-Directed Conjugation of Clicked Glycopolymers To Form Glycoprotein Mimics. Haddleton, D. M., Mantovani, G.; Lindqvist, J.; Jones, M. W.; Brayden, D.; Ryan, S.; Randev, R.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 1089

[12] Nanostructured Latex Particles Directly Obtained by Nitroxide-Mediated Emulsion Polymerization. Nicolas, J.; Ruzette, A.-V.; Charleux, B.; Magnet, S.; Gérard, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 205

[11] Toward the Synthesis of Clickable, Stealth Nanoparticles Based on Poly(alkyl cyanoacrylate). Nicolas, J.; Borretto, E.; Desmaële, D.; Andrieux, K.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 488

[10] Nitroxide-Mediated Controlled Free-Radical Polymerization of Poly(ethylene Glycol)-Based Monomers. Nicolas, J.; Couvreur, P.; Charleux, B. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200849, 215


2006

[9] Fluorescently Tagged Bioconjugates from Living Radical Polymerization Using Protein Macroinitiators. San Miguel, V.; Nicolas, J.; Mantovani, G.; Haddleton, D. M. PMSE Prepr. (Am. Chem. Soc., Div. Polym. Mater. Sci. Eng.) 200695, 1064

[8] Nanoparticles Synthesized by Novel Nitroxide-Mediated Emulsion Polymerization Processes. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200647, 903

[7] Bioconjugation onto a Biological Surface Using Fluorescent Polymers Synthesized by Living Radical Polymerization. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200647, 15

[6] Strong Improvement of Nitroxide-Mediated Polymerizations of Methyl Methacrylate by a Copolymerization Approach: Polymer Synthesis and Characterizations. Nicolas, J.; Mueller, L.; Belleney, J.; Charleux, B. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006


2005

[5] Polymerization in Aqueous Dispersed Media Stabilized by Polyelectrolyte Copolymers. Delaittre, G.; Houillot, L.; Lefay, C.; Manguian, M.; Nicolas, J.; Chassenieux, C.; Save, M.; Charleux, B. 2nd Workshop of the Young European Scientists (YES 2005), Krakow, Poland, September 13-18, 2005, P_056[2005]

[4] Strong Improvement of Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate via a Copolymerization Approach. Nicolas, J.; Charleux, B.; Guerret, O. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200546, 403

[3] Use of a Novel Class of SG1-Based Water-Soluble Dialkoxyamine in Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 200546, 484


2004

[2] Water-Soluble Alkoxyamine: Application as New Initiator in Aqueous Dispersed Systems. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1027

[1] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization with a Novel SG1-Based Water-Soluble Alkoxyamine. Nicolas, J.; Delaittre, G.; Lefay, C.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1054

Oral communications


International oral communications


2017

[38] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. International Conference On Nanomedicine And Nanobiotechnology (ICONAN) 2017, Barcelona, Spain, September 25.-27, 2017. [Plenary]

[37] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. 252nd ACS National Meeting, Washington, DC, United States, August 20-24, 2017. [Invited]

[36] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. Advanced Polymers via Macromolecular Engineering (APME) 2017 congress, Ghent, Belgium, May 21-25, 2017. [Invited]


2016

[35] Comb-like PEG-based Vinyl Copolymers for Biomedical Applications. Nicolas, J. 252nd ACS National Meeting, Philadelphia, PA, United States, August 21-25, 2016. [Invited]

[34] Vinyl Polymers for Biomedical Applications. Nicolas, J. Warwick Polymer Conference 2016, University of Warwick, Coventry, U.K., July 11-14, 2016. [Invited]

[33] Degradable PEG-Based Materials by Nitroxide-Mediated Radical Ring-Opening Copolymerization. Nicolas, J. Belgian Polymer Group annual meeting 2016, Hasselt, Belgium, 23-24 May, 2016. [Invited]

[32] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical (PBP) Technology, Glasgow, UK, 4-7 April, 2016. [Invited]

[31] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 11th International Conference and Workshop on Biological Barriers, Helmotz-Institute for Pharmaceutical Research and Saarland University, Saarbrücken, Germany, 7-9 March, 2016. [Invited]


2015

[30] Nitroxide-Mediated Radical Ring-Opening Copolymerization: A Single Cyclic Ketene Acetal Comonomer to Control the Polymerization of Methacrylates and to Confer Degradability. Delplace, V.; Harrisson, S.; Guillaneuf, Y.; Gigmes, D.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015. [Invited]

[29] Conjugation and Bioconjugation from α-Functional Polymers Obtained by Nitroxide-Mediated Polymerization (NMP) Initiated by N-Hydroxysuccinimidyl- or Azlactone-Functionalized Alkoxyamines. Delplace, V.; Harrisson, S.; Guillaneuf, Y.; Pascual, S.; Fontaine, L.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015

[28] The Drug-Initiated Method: a Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles. Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P.; Nicolas, J. International Chemical Congress of the Pacific Basin Societies (Pacifichem 2015), Honoluu, Hawai, USA, 15-20 December, 2015

[27] Advanced Polymer Nanoparticles For Efficient Drug Delivery. Nicolas, J. Applied Nanotechnology and Nanoscience International Conference (ANNIC 2015), Paris, France, 5-7 November, 2015. [Plenary]

[26] The Drug-Initiated Method: A Convenient Way for the Synthesis of Efficient Anticancer Polymer Prodrug Nanoparticles. Nicolas, J. International Symposium on Amphiphilic Polymers Networks, Gels and Membranes (APNGM15), Budapest, Hungary, 30 August–2 September, 2015. [Invited]


2014

[25] Advanced Polymer Nanoparticles for Drug Delivery. Nicolas, J. 4th Zing Polymer Chemistry Conference, Cancún, Mexico, December 10-13 2014. [Invited]

[24] Novel Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014. [Invited]

[23] Novel Multifunctional Polymer Nanoparticles for Active Targeting in Drug Delivery: Application to Cancer and Alzheimer's Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Andrieux, K.; Couvreur, P. 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014

[22] Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Nicolas, J.; Mackiewicz, N.; Handké, N.; Lakkiredy, H. R.; Bazile, D.; Couvreur, P. European Polymer Conference (EUPOC), Precision Polymers: Synthesis, Folding and Function, Gargnano, Italy, May 25-29, 2014


2013

[21] Novel Polyisoprenoid Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 3rd Conference on “Innovation in Drug Delivery: Advances in Local Drug Delivery”, Pisa, Italy, September 22-25, 2013

[20] Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Harrisson, S.; Nicolas, J.; Maksimenko, A.; Mougin, J.; Couvreur, P. European Polymer Federation (EPF) congress, Pisa, Italy, June 16-21, 2013


2012

[19] Gemcitabine-Polyisoprenoid Nanoparticles for Cancer Therapy. Nicolas, J.; Bui-Duc, T.; Maksimenko, A.; Harrisson, S.; Desmaële, D.; Couvreur, P. 244th ACS National Meeting, Philadelphia, PA, United States, August 19-23, 2012. [Invited]

[18] Dual Active Targeting Using a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Salvati, E.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. Macro Group UK International Conference on Polymer Synthesis, University of Warwick, U.K., July 9-12, 2012. [Invited]

[17] Poly(alkyl cyanoacrylate) Nanoparticles as a versatile Platform against Cancer and Alzheimer’s disease. Nicolas, J. 3rd International Congress Nanotechnology in Medicine & Biology (BioNanoMed), Krems, Austria, March 1-2, 2012. [Invited]


2011

[16] Design of Innocuous and Functional Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Nicolas, J.; Chenal, M.; Mura, S.; Harrisson, S.; Couvreur, P. 6th Spin Conference, Marseille, France, September 26-29, 2011

[15] Design of Innocuous Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Chenal, M.; Mura, S.; Harrisson, S.; Couvreur, P.; Nicolas, J. 242nd ACS National Meeting, Denver, CO, United States, August 28 - September 1, 2011. [Invited]

[14] Advanced Poly(alkyl cyanoacrylate) Nanoparticles for Cell Imaging and Against Alzheimer's Disease. Nicolas, J.; Brambilla, D.; Le Droumaguet, B.; Verpillot, R.; Taverna, M.; Gobbi, M.; Salmona, M.; Couvreur, P.; Andrieux, K.. Sydney 2011 International Nanomedicine Conference, Coogee Beach, Australia, July 14-16, 2011. [Invited]

[13] Advanced Poly(alkyl cyanoacrylate) Nanoparticle for Cell Imaging and Against Alzheimer's Disease.Nicolas, J. EuroNanoForum, Budapest, Hungary, May 30 - June 1, 2011


2010

[12] Advanced Poly(alkyl cyanoacrylate) Nanoparticles As Promising Therapeutic Agents for Alzheimer's Disease And Intracellular Trafficking. Brambilla, D.; Nicolas, J.; Verpillot, R.; Le Droumaguet, B.; Taverna, M.; Gobbi, M.; Canovi, M.; Couvreur, P.; Andrieux, K. 43rd MACRO IUPAC World Polymer Congress, Glasgow, UK, July 11-17, 2010

[11] Novel Materials From Nitroxide-Mediated Polymerization of Methacrylic Esters. Nicolas, J.; Brusseau, S.; Dire, C.; Couvreur, L.; Magnet, S.; Charleux, B. 43rd MACRO IUPAC World Polymer Congress, Glasgow, UK, July 11-17, 2010


2009

[10] Advanced Poly(alkyl cyanoacrylate) Nanoparticles for Drug Delivery Purposes. Nicolas, J.; Le Droumaguet, B.; Brambilla, D; Andrieux, K.; Couvreur, P. 11th Pacific Polymer Conference, Cairns, Australia, December 6-10, 2009. [Invited]

[9] Nitroxide-Mediated Controlled Radical Copolymerization and its Application to Methacrylate Monomers. Charleux, B., Nicolas, J.; Dire, C.; Brusseau, S.; Magnet, S.; Couvreur, L. 11th Pacific Polymer Conference, Cairns, Australia, December 6-10, 2009

[8] Synthesis of Highly Functionalized Nanoparticles Based on Poly(alkyl cyanoacrylate) by Means of Click Chemistry. Le Droumaguet, B.; Bensaid, F.; Roisin, J.; Andrieux, K.; Couvreur, P.; Nicolas, J. 17th International Symposium on Microencapsulation, Nagoya, Japan, September 29 - October 1, 2009

[7] Nanoparticles For Therapy of Alzheimer's Disease: Ability of PEGylated Poly(alkyl cyanoacrylate) Nanoparticles to Link to the Aβ Peptide 1-42 and to Influence its Aggregation Kinetics. Brambilla, D.; Verpillot, R.; Nicolas, J.; Taverna, M.; Couvreur, P.; Andrieux, K. 17th International Symposium on Microencapsulation, Nagoya, Japan, September 29 - October 1, 2009


2008

[6] Nanostructured Latex Particles Directly Obtained by Nitroxide-Mediated Emulsion Polymerization. Nicolas, J.; Ruzette, A.-V.; Charleux, B.; Magnet, S.; Gérard, P. 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008. [Invited]


2006

[5] Fluorescently Tagged Bioconjugates from Living Radical Polymerization Using Protein Macroinitiators. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[4] Nanoparticles Synthesized by Novel Nitroxide-Mediated Emulsion Polymerization Processes Nicolas, J.; Charleux, B.; Magnet, S. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[3] Bioconjugation onto a Biological Surface Using Fluorescent Polymers Synthesized by Living Radical Polymerization Nicolas, J.; Haddleton, D. M., Khoshdel, E. 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006

[2] Use of Novel SG1-Based Water-Soluble Alkoxyamines in Nitroxide-Mediated Emulsion Polymerization Processes. Nicolas, J.; Charleux, B.; Magnet, S. Macro Group UK International Conference on Polymer Synthesis, University of Warwick, U.K., August 31 - September 1, 2006


2004

[1] Nitroxide-Mediated Controlled Free-Radical Polymerization in Aqueous Dispersed Media Using a SG1-Based Water-Soluble Alkoxyamine Initiator. Nicolas, J.; Charleux, B.; Magnet, S.; Guerret, O. International Symposium on Polymers in Dispersed Media (PDM), ENS, Lyon, France, April 4-8, 2004

 

National oral communications


2017

[10] New Polymers and Strategies for Drug Delivery Applications. Nicolas, J. 46th French Polymer Society (GFP) Meeting, ENSAM, Paris, France, November 21-24, 2017.

[9] Vinyl Polymers for Biomedical Applications. Nicolas, J. 45ème Journées d'Etudes des Polymères (JEPO), Gravelines, France, October 1-6, 2017. [Invited]


2016

[8] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. 45th French Polymer Society (GFP) Meeting, Marseille, France, November 15-18, 2016. [Invited]

[7] Polymer Nanoparticles for Biomedical Applications. Nicolas, J. 7ème journée GFP-IdF, "Polymères fonctionnels : de la chimie aux propriétés", ICPME, Université Paris-Est, Thiais, July 8, 2016. [Invited]


2015

[6] The Drug-Initiated Method: A New Route to More Potent Nanoparticles for Anticancer Therapy. Harrisson, S.; Maksimenko, A.; Bui, D. T.; Couvreur, P.; Nicolas, J. 2015 French Chemical Society meeting SCF'15, Lille, France, July 7-9, 2015.


2013

[5] Novel Polyisoprenoid Nanoparticles with In Vivo Anticancer Activity from Well-Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. 30ème Réunion du Club Emulsion, ENSCM, Montpellier, France, September 26-27, 2013


2012

[4] Utilisation des Nanoparticules de Polymère dans le Domaine du Ciblage. Nicolas, J. Journée scientifique de l’ICMPE: Santé et Interface avec le Vivant, Université Paris-Est, September 11, 2012. [Invited]

[3] Advanced Poly(Alkyl Cyanoacrylate) Nanoparticles for Specific Targeting and Imaging Purposes. Nicolas, J. CopAmphi 2012. Copolymères amphiphiles : synthèse, organisation, applications. Toulouse, France, June 5-7, 2012. [Invited]


2010

[2] Nanoparticules de Poly(alkyl cyanoacrylate) : Fonctionnalisation, Imagerie Intracellulaire et Interactions avec le Peptide Amyloïde Aβ. Nicolas, J. 23ème Colloque du Biotechnocentre, Tour, France, 21-22 Octobre, 2010. [Invited]


2004

[1] Polymérisation Radicalaire Contrôlée en Milieux Aqueux Dispersés par les Nitroxides - Utilisation d'une Alcoxyamine Hydrosoluble à Base SG1. Nicolas, J.; Charleux, B.; Magnet, S.; Guerret, O. 32ème Journées d'Etudes des Polymères (JEPO), La Brosse Montceaux, France, September 19-24, 2004

 

Invited seminars


2017

[15] Innovative Polymers for Drug Delivery Applications. Nicolas, J. Division Chimie de l’Académie des Sciences, Paris, France, September 19, 2017

[14] Vinyl Polymers for Biomedical Applications. Nicolas, J. Conférences et Séminaires de l'ESPCI, ESPCI, Paris, France, March 24, 2017

[13] Drug-Initiated Synthesis of Polymer Prodrug Nanoparticles. Nicolas, J. Minisymposium - Polymers for Medicine, Institute of Materials (IMX), EPFL, Lausanne, Switzerland, March 17, 2017


2016

[12] Advanced Polymer Nanoparticles Against Cancer and the Alzheimer's Disease. Nicolas, J. University of Osaka, Osaka, Japan, October 24, 2016

[11] Vinyl Polymers for Biomedical Applications. Nicolas, J. Macromolecular Architectures (MacroArc) Research Team, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, January 27, 2016

[10] Advanced Polymer Nanoparticles Against Cancer and the Alzheimer's Disease. Nicolas, J. Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany, January 26, 2016


2015

[9] Design of Polymer Nanoparticles Against Cancer and the Alzheimer's Disease. Nicolas, J. Institut Charles Sadron (ICS), Strasbourg, France, February 3, 2015


2014

[8] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Département de Chimie Moléculaire, Université Joseph Fourier, Grenoble, May 22, 2014

[7] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Institut de Chimie et des Matériaux Paris-Est, UMR CNRS 7182, Université Paris-Est, Paris, May 13, 2014

[6] Design of Polymeric Nanoparticles for Biomedical Applications. Nicolas, J. Laboratoire de Chimie des Polymères, Institut Parisien de Chimie Moléculaire (IPCM), Université Pierre et Marie Curie, Paris, April 4, 2014


2013

[5] Polymeric Nanoparticles for Drug Delivery and Targeting Purposes. Nicolas, J. Service de Chimie Bioorganique et de Marquage (SCBM), CEA, Saclay, September 17, 2013

[4] Polymeric Nanoparticles for Drug Delivery and Targeting Purposes. Nicolas, J. Winter School, NAMDIATREAM European project, Villars‐sur‐Ollon, Switzerland, March 3-6, 2013


2012

[3] Nitroxide-Mediated Polymerization: From Kinetics to Biomaterials. Nicolas, J. UCO2M, UMR CNRS 6011, Université du Maine, April 10, 2012


2011

[2] Controlled/Living Radical Polymerization and its Application to the design of Protein/Peptide-Polymer Bioconjugates. Nicolas, J. PeptiSyntha, Solvay, Bruxelles, December 19, 2011

[1] NMP is Coming Home with Some Stories to Tell. Nicolas, J. CMAD, University of New South Wales, Sydney, Australia, July 13, 2011

Vacancies

Post-Doc Vacancies for an ERC Consolidator Grant project

Speciality: organic and/or polymer chemistry with expertise in colloids, bioconjugation, medicinal chemistry or drug delivery
Starting date: September 2018
Duration: 2 years

Read more


PhD Vacancies for an ERC Consolidator Grant project

Speciality: organic and/or polymer chemistry with expertise in colloids, bioconjugation, medicinal chemistry or drug delivery
Starting date: January 2019
Duration: 3 years

Read more

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